柴黄口服液对鸡传染性支气管炎的临床效果

Clinical Effect of Chaihuang Oral Liquid on Infectious Bronchitis in Chickens

为了观察柴黄口服液对鸡传染性支气管炎(IB)的临床效果,本试验将经病原检测确诊为IB的患病鸡,随机分为2个组,分别为试验组(按2.5 mL/L饮水量给予柴黄口服液+1 g/L饮水量给予20%氟苯尼考粉)和对照组(按1 g/L饮水量给予20%氟苯尼考粉),连续给药5 d,观察用药前后各组鸡只的临床症状、病理剖检变化、脏器指数和组织病理学变化等指标,评价柴黄口服液在常规养殖环境中对鸡IB的治疗效果。结果显示,用药5 d后,与对照组相比,试验组鸡只呼吸道疾病所引起的临床症状减轻,死亡率降低1.7%,平均末重提高18.47%(P<0.01),平均增重提高37.36%(P<0.01);气管内和气囊壁黏性渗出物减少;肺脏、肝脏和脾脏指数稍有升高,但差异不显著(P>0.05)。组织病理学观察结果显示,对照组鸡只的气管、肺脏和肠道等器官组织学结构均发生不同程度的血管扩张充血、黏膜上皮脱落等病变,试验组鸡只的气管、肺脏和肠道器官组织学结构均未见明显异常;2个组鸡只的肾脏均出现肾小球萎缩和肾小管上皮细胞变性坏死等病变。结果表明,柴黄口服液对鸡IB具有较好的治疗作用,其可以保护鸡只气管、肺脏和肠道组织结构的完整性,同时提高鸡只的生产性能,降低死亡率。

To observe the clinical efficacy of Chaihuang oral liquid on infectious bronchitis(IB)in chickens,this study selected diseased chickens diagnosed by pathogen detection and randomly divided them into two groups:the experimental group(Chaihuang oral liquid at 2.5 mL/L drinking water+20%florfenicol powder at 1 g/L drinking water)and the control group(20%florfenicol powder at 1 g/L drinking water).The treatment was administered continuously for 5 days.Clinical symptoms,pathological changes,organ index,and histopathological changes in chickens before and after administration were observed to evaluate the therapeutic effect of Chaihuang oral liquid on chicken IB in conventional farming environments.The results showed that after 5 days of administration,compared with the control group,the clinical symptoms of respiratory diseases in the experimental group were alleviated,the mortality rate decreased by 1.7%,the average final weight increased by 18.47%(P<0.01),and the average weight gain increased by 37.36%(P<0.01).The sticky exudates in the trachea and air sac walls decreased,and the indices of lungs,liver,and spleen slightly increased,but the differences were not significant(P>0.05).Histopathological observations showed that the organ histological structure,including the trachea,lungs,and intestines,in the control group chickens exhibited varying degrees of lesions such as vascular dilation,congestion,and mucosal epithelial shedding.In contrast,the experimental group chickens showed no significant abnormalities in the histological structure of the trachea,lungs,and intestines.Both groups of chickens exhibited lesions in the kidneys,including glomerular atrophy and degeneration and necrosis of renal tubular epithelial cells.The results indicate that Chaihuang oral liquid has a good therapeutic effect on chicken IB,protecting the integrity of the trachea,lungs,and intestinal tissues,while improving chicken productivity and reducing mortality.