化瘀通脉汤剂联合阿托伐他汀对心绞痛患者hs-CRP、MCP-1及bFGF的影响

Effect of Huayu Tongmai Decoction combined with atorvastatin on hs CRP,MCP⁃1,andbFGF in patients with angina pectoris

目的 探讨化瘀通脉汤剂联合阿托伐他汀治疗心绞痛的有效性及对超敏C反应蛋白(hs-CRP)、单核细胞趋化蛋白-1(MCP-1)及碱性成纤维细胞生长因子(bFGF)的影响。方法 选择2018年1月至2022年11月于沭阳县中医院接受治疗的80例心绞痛患者,采用随机数表法分为试验组(n=41)和对照组(n=39)。对照组给予阿托伐他汀治疗,试验组给予化瘀通脉汤剂联合阿托伐他汀治疗。比较两组临床疗效、hs-CRP、MCP-1、bFGF、心绞痛发作频率、持续时间及中医症状评分水平变化情况及并发症发生情况。结果 治疗后,试验组总有效率为92.68%,显著高于对照组的76.92%,差异有统计学意义(P<0.05);治疗后两组血清hs-CRP、MCP-1水平均降低,且试验组降低更为明显,两组bFGF水平均升高,且试验组升高更为明显,差异有统计学意义(P<0.05);治疗后,两组发作频率、持续时间均降低,且试验组降低更为明显,差异有统计学意义(P<0.05);治疗后,两组胸闷、胸痛、心悸及气短评分均显著降低,且试验组低于对照组,差异有统计学意义(P<0.05);两组术后并发症主要为恶心呕吐、头晕及腹泻,两组并发症发生率比较差异无统计学意义(P>0.05)。结论 化瘀通脉汤剂联合阿托伐他汀治疗心绞痛具有较好的效果,可明显改善心绞痛症状及中医证候,推测可能与其可有效改善hs-CRP、MCP-1及bFGF水平有关。

Objective To study the effect of Huayu Tongmai Decoction combined with atorvastatin on angina pectoris and its effect on hypersensitive C-reactive protein(hs-CRP),monocyte chemotactic protein-1(MCP-1)and basic fibroblast growth factor(bFGF).Methods 80 patients with angina pectoris who received treatment in Shuyang County Hospital of Traditional Chinese Medicine from January 2018 to November 2022 were selected and divided into the experimental group(n=41)and the control group(n=39)by random number table method.The control group was treated with atorvastatin,and the experimental group was treated with Huayu Tongmai Decoction combined with atorvastatin.The clinical efficacy,hs-CRP,MCP-1,bFGF,angina attack frequency,duration,TCM symptom score and the incidence of complications were compared between the two groups.Results After treatment,the total effective rate of the experimental group was 92.68%,which was significantly higher than that of the control group(76.92%),and the difference was statistically significant(P<0.05).After treatment,the serum hs-CRP and MCP-1 levels were decreased in 2 groups,and the decrease was more obvious in the experimental group,while the bFGF level was increased in 2 groups,and the increase was more obvious in the experimental group,the difference was statistically significant(P<0.05).After treatment,the frequency and duration of attack were decreased in both groups,and the decrease in the experimental group was more obvious,with statistical significance(P<0.05).After treatment,the scores of chest tightness,chest pain,palpitation,and shortness of breath in 2 groups were significantly decreased,and the test group was lower than the control group,the difference was statistically significant(P<0.05).The main postoperative complications were nausea,vomiting,dizziness and diarrhea,and there was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion Huayu Tongmai Decoction combined with atorvastatin has a good effect in the treatment of angina pectoris,which can significantly improve the symptoms and TCM syndromes of angina pectoris.It may be related to the effective improvement of hs-CRP,MCP-1 and bFGF levels.