肺癌患者Bmi-1、Caspase-3、EAF2蛋白表达及其临床意义

Expression of Bmi⁃1,caspase⁃3 and EAF2 proteins in lung cancer patients and their clinical significance

目的 观察肺癌患者的Bmi-1、Caspase-3蛋白、EAF2蛋白表达情况,并分析其临床意义。方法 选取2020年2月至2022年8月在运城市中心医院接受手术治疗的肺癌患者100例为研究对象,观察患者癌组织和癌旁组织(癌旁距离2 cm)Bmi-1、Caspase-3蛋白、EAF2蛋白表达的差异,比较TNM分期、是否存在淋巴结转移、肿瘤分化程度、肿瘤大小等不同临床病理特征中Bmi-1、Caspase-3蛋白、EAF2蛋白表达差异,采用多因素Logistic回归分析影响肺癌患者Bmi-1、Caspase-3蛋白、EAF2蛋白表达的因素。结果 肺癌患者癌组织Bmi-1、Caspase-3阳性表达率较癌旁组织高,EAF2阳性表达率较癌旁组织低,差异有统计学意义(χ^(2)=46.154、98.000、60.652;P<0.05);TNM分期为Ⅲ期、有淋巴结转移、分化程度为低分化、肿瘤大小≥3 cm的肺癌患者Bmi-1、Caspase-3阳性表达率较高(χ^(2)=31.049、32.773、25.445、7.563、10.882、24.370、35.065、7.563;P<0.05),EAF2阳性表达率较低(χ^(2)=17.582、7.441、23.645/4.762;P<0.05),不同年龄、性别的肺癌患者Bmi-1、Caspase-3、EAF2表达差异无统计学意义(χ^(2)=1.515、1.307、0.001、0.499、0.495、0.001;P>0.05);多因素Logistic回归分析显示,淋巴结转移、TNM分期是影响肺癌患者Bmi-1、Caspase-3蛋白、EAF2蛋白表达的因素(P<0.05)。结论 肺癌患者的Bmi-1、Caspase-3阳性表达率较高,EAF2阳性表达率较低,且与患者的分期、淋巴结转移情况密切相关。

Objective To observe the expression of Bmi-1,Caspase-3 and EAF2 in lung cancer patients and analyze their clinical significance.Methods A total of 100 patients with lung cancer who received surgical treatment in Yuncheng Central Hospital from February 2020 to August 2022 were selected as the study objects to observe the differences in the expression of Bmi-1,caspase-3 protein and EAF2 protein in cancer tissues and adjacent tissues(2cm away from the adjacent tissues).The expression differences of Bmi-1,caspase-3 protein and EAF2 protein in different clinicopathologic characteristics such as TNM stage,presence of lymph node metastasis,tumor differentiation degree and tumor size were compared.Multivariate logistic regression was used to analyze the factors affecting the expression of Bmi-1,caspase-3 and EAF2 proteins in lung cancer patients.Results The positive expression rates of Bmi-1 and caspase-3 in lung cancer tissues were higher than those in adjacent tissues,and the positive expression rates of EAF2 were lower than those in adjacent tissues,the difference was statistically significant(X^(2)=46.154,98.000,60.652;P<0.05).The positive expression rates of Bmi1 and caspase-3 were higher in patients with TNM stageⅢ,lymph node metastasis,low differentiation and tumor size≥3 cm(X^(2)=31.049,32.773,25.445,7.563,10.882,24.370,35.065,7.563,P<0.05),the positive expression rate of EAF2 was low(X^(2)=17.582,7.441,23.645/4.762;P<0.05),there were no significant differences in the expression of Bmi-1,caspase-3 and EAF2 in different ages and genders(X^(2)=1.515,1.307,0.001,0.499,0.495,0.001;P>0.05).Multivariate Logistic regression analysis showed that lymph node metastasis and TNM stage were the factors affecting the expression of Bmi-1,caspase-3 protein and EAF2 protein in lung cancer patients(P<0.05).Conclusion The positive expression rates of Bmi-1 and caspase-3 were higher in patients with lung cancer,and the positive expression rates of EAF2 were lower,which were closely related to the stage and lymph node metastasis of patients.