外泌体在常见精神障碍诊治中的研究进展

Research progress on the role of exosomes in the diagnosis and treatment of psychiatric disorders

精神障碍的发病机制涉及神经炎症、突触可塑性和神经再生等过程,然而精神障碍的诊治较困难,预后也较差,因此寻找新的生物标志物及治疗方法较为重要。外泌体作为细胞自身分泌的一种纳米膜性囊泡,不仅在多种疾病的病理生理过程中发挥重要作用,也参与精神疾病的发生与发展。本文对外泌体在常见精神障碍诊治中作用的研究进展进行综述,为进一步将外泌体精准应用于精神障碍诊治中提供理论参考。

The pathogenesis involves neuroinflammation,synaptic plasticity and nerve regeneration.However,the diagnosis and treatment of these diseases are difficult,and the prognosis is poor.As a result,it is particularly important to find new biomarkers and therapeutic methods.Exosomes,as nanoscale membranous vesicles secreted by cells themselves,not only play an important role in the pathophysiological processes of various diseases,but also participate in the occurrence and development of mental disorders.This paper summarizes the research progress on the role of exosomes in the diagnosis and treatment of common mental disorders,providing specific theoretical references for the precise application of exosomes in the diagnosis and treatment of mental disorders in the futures.