QT间期延长导致心血管事件与猝死的相关机制

Related mechanisms of cardiovascular events and sudden death due to QT interval prolongation

本文综述QT间期延长的定义、测量方法,列举QT间期延长导致恶性室性心律失常和心脏性猝死的一些临床研究证据,总结了QT间期延长导致心血管事件和猝死的发生机制可能与QT间期离散度增加、心肌电兴奋-机械收缩耦联不协调和心脏自主神经功能调节不平衡等多元化因素的相互作用密切相关。因此,建议临床医生高度关注某些药物可能引发的获得性QTc延长,以免造成不良后果。

This paper reviews the definition and measurement methods of QT interval prolongation,lists some clinical research evidences that QT interval prolongation leads to malignant ventricular arrhythmia and sudden cardiac death.It concludes that the mechanism of cardiovascular events and sudden death due to QT interval prolongation may be closely related to the interaction of multiple factors such as increased QT interval dispersion,uncoordinated coupling of myocardial electrical excitation and mechanical contraction,and imbalance in cardiac autonomic function regulation.It is suggested that clinicians should be highly alerted to the risk of acquired QTc prolongation caused by certain drugs in order to avoid adverse outcomes.