急性一氧化碳中毒脑损伤的磁共振研究进展

Development of MRI Study of Brain Injury in Acute Carbon Monoxide Poisoning

一氧化碳(CO)中毒是临床上常见的意外中毒之一。由于高代谢及能量需求,中枢神经系统是急性CO中毒(ACMP)中最易受损的结构。ACMP脑损伤引起的直接症状发生在接触后即刻,可以持续存在,也可能经过假愈期后,出现急性CO中毒迟发性脑病,其涉及复杂的病理生理机制,严重影响患者的生存质量。近年来,随着磁共振技术的发展,ACMP所致脑损伤的发病机制、病理生理改变及神经影像学模式得到了进一步研究,本文就磁共振新技术在ACMP脑损伤中的应用现状进行综述,并展望未来的研究方向。

Carbon monoxide(CO)poisoning is one of the common accidental poisonings in clinic.Due to high metabolism and energy demand,the central nervous system is the most vulnerable structure in acute carbon monoxide poisoning(ACMP)patients.The direct symptoms caused by ACMP-induced brain injury occur immediately after exposure.It can persist,or it may develop delayed encephalopathy after acute carbon monoxide poisoning after recovery with a lucid interval,which involves complex pathophysiological mechanisms and seriously affects the quality of life of patients.With the development of magnetic resonance technology,the pathogenesis,pathophysiological changes,and neuroimaging patterns of ACMP-induced brain injury have been further studied.In this article,the application status of new magnetic resonance technology in ACMP-induced brain injury was reviewed,and the future research direction was prospected.