PRV感染后对宿主先天免疫信号转导影响的研究进展

Research progress on effect of PRV infection on host innate immune signal transduction

伪狂犬病病毒(pseudorabies virus,PRV)是伪狂犬病(pseudorabies,PR)的病原体,感染大多数哺乳动物,自发现以来,已在世界各地流行,并给养猪业造成了巨大的经济损失。近年来,为预防和治疗PR,对PRV的致病机制进行了深入研究,在PRV感染后引起宿主先天免疫信号转导的变化,以及对宿主免疫反应的影响等方面都取得了一定进展,但仍有很多信号通路与病毒的作用机制还有待揭示。因此,本文以PRV感染后结合不同受体引起下游信号通路的变化为出发点,将病毒与宿主间相互作用的研究进展进行综述,以期为PRV致病机制和抗病毒药物的后续研究提供参考。

Pseudorabies virus(PRV)is the causative agent of pseudorabies(PR)that infects most mammals.Since its discovery,it has become popular all over the world and has caused huge economic losses to the pig industry.In recent years,to prevent and treat PR,the pathogenic mechanism of PRV has been deeply studied,and some progress has been made in the changes of host innate immune signal transduction after PRV infection,as well as the impact on host immune response,but there are still many signaling pathways and virus mechanisms to be revealed.Therefore,this paper reviews the research progress of virus-host interaction by binding to different receptors after PRV infection,in order to provide reference for the subsequent research on the pathogenic mechanism of PRV and antiviral drugs.