三七中的化学成分在不同抑郁症模型中的作用和机制研究进展

Research Progress on the Role and Mechanism of Chemical Components inPanax Notoginseng in Different Depression Models

抑郁症是一种常见的精神障碍疾病,具有高度致残性、致命性。西医中通常口服抗抑郁药进行治疗,但其治疗周期长、副作用明显、价格高和依从性差,反应率有限、疗效延迟等限制了其应用。越来越多的研究揭示了中药在抑郁症治疗中具有突出的疗效,可作为抑郁症的前瞻性替代疗法。三七是我国中药材,现代研究发现其具有抑制神经元凋亡、抑制血小板聚集、抗氧化、抗炎、神经元保护等药理作用。近年来,三七针对各种抑郁症模型的治疗效果及药理学研究产生了大量的实验数据,然而,三七及其化学成分对抑郁症的潜在影响及机制尚未完全确定。因此,本文综述了三七中的主要化学成分在不同抑郁症模型中的抗抑郁机制,为明确三七抗抑郁的作用机制、推进抑郁症中医药新疗法和新药研发提供理论依据。

Depression is a common mental disorder,which is highly disabling and fatal.Western medicine usually uses oral antidepressants for treatment,but their long treatment cycle,obvious side effects,high price,poor compliance,limited response rate,and delayed efficacy limit their application.More and more studies have revealed that traditional Chinese medicine has outstanding therapeutic effects in the treatment of depression and can serve as a prospective alternative therapy for depression.Panax notoginseng is a traditional Chinese medicinal herb in China.Modern research has found that it has pharmacological effects such as inhibiting neuronal apoptosis,inhibiting platelet aggregation,antioxidant,anti-inflammatory,and neuronal protection.In recent years,a large amount of experimental data has been generated on the therapeutic effects and pharmacological studies of Panax notoginseng on various depression models.However,the potential impact and mechanism of Panax notoginseng and its chemical components on depression have not been fully determined.Therefore,this paper reviews the antidepressant mechanisms of the main chemical components in Panax notoginseng in different depression models,providing a theoretical basis for clarifying the antidepressant mechanism of Panax notoginseng and promoting the development of new traditional Chinese medicine therapies and drugs for depression.