紫杉醇联合卡铂化疗同步调强适形放疗治疗晚期宫颈癌的效果分析

Effect of paclitaxel combined with carboplatin chemotherapy and intensity modulated conformal radiotherapy in the treatment of advanced cervical cancer

目的探讨紫杉醇联合卡铂化疗同步调强适形放疗治疗晚期宫颈癌的效果。方法80例晚期宫颈癌患者,随机分为对照组和观察组,每组40例。对照组采用调强适形放疗,观察组采用紫杉醇联合卡铂化疗同步调强适形放疗。对比两组患者局部复发率、治疗后生活质量评分、不良反应发生率及2年生存率。结果观察组局部复发率为10.00%,明显低于对照组的32.50%,差异具有统计学意义(P<0.05)。治疗后,观察组躯体功能评分为(76.77±5.74)分、心理功能评分为(76.56±5.56)分、社会功能评分为(75.57±4.74)分、物质生活评分为(76.46±5.96)分,明显高于对照组的(73.75±5.12)、(72.46±5.24)、(71.66±3.74)、(70.87±5.39)分,差异均有统计学意义(P<0.05)。观察组不良反应发生率为20.00%(8/40),明显低于对照组的42.50%(17/40),差异具有统计学意义(P<0.05)。观察组2年生存率为75.00%,明显高于对照组的52.50%,差异有统计学意义(P<0.05)。结论采用紫杉醇联合卡铂化疗同步调强适形放疗治疗晚期宫颈癌可提高患者生存率,降低疾病复发率、不良反应发生率与痛苦程度,提高患者生活质量,具有较高的临床价值,值得进一步推广使用。

Objective To discuss the effect of paclitaxel combined with carboplatin chemotherapy and intensity modulated conformal radiotherapy in the treatment of advanced cervical cancer.Methods A total of 80 patients with advanced cervical cancer were randomly divided into a control group and an observation group,with 40 cases in each group.The control group received intensity-modulated conformal radiotherapy,and the observation group received paclitaxel combined with carboplatin chemotherapy and intensity modulated conformal radiotherapy.The local recurrence rate,quality of life score after treatment,incidence of adverse reactions and 2-year survival rate were compared between the two groups.Results The local recurrence rate of the observation group was 10.00%,which was significantly lower than that of 32.50%of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of physical function,psychological function,social function and material life in the observation group were(76.77±5.74),(76.56±5.56),(75.57±4.74)and(76.46±5.96)points,which were significantly higher than those of(73.75±5.12),(72.46±5.24),(71.66±3.74)and(70.87±5.39)points in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 20.00%(8/40),which was significantly lower than that of 42.50%(17/40)in the control group,and the difference was statistically significant(P<0.05).The 2-year survival rate in the observation group was 75.00%,which was significantly higher than that of 52.50%in the control group,and the difference was statistically significant(P<0.05).Conclusion Paclitaxel combined with carboplatin chemotherapy and intensity modulated conformal radiotherapy can improve the survival rate of patients with advanced cervical cancer,reduce the recurrence rate,the incidence of adverse reactions and the degree of pain of patients,and improve the quality of life of patients.It has high clinical value and is worthy of further popularization and use.