乙酰半胱氨酸联合布地奈德雾化吸入治疗儿童支气管肺炎的疗效分析

Efficacy analysis of acetylcysteine combined with budesonide aerosol inhalation on children with bronchopneumonia

目的探究乙酰半胱氨酸联合布地奈德雾化吸入治疗儿童支气管肺炎的临床疗效。方法200例支气管肺炎患儿,根据随机数字表法分为观察组和对照组,每组100例。对照组实行常规治疗,观察组在常规治疗基础上行乙酰半胱氨酸联合布地奈德雾化吸入治疗。对比两组患儿的治疗效果、不良反应发生情况、临床症状消失时间。结果观察组患儿治疗总有效率为99%,高于对照组的87%,差异具有统计学意义(P<0.05)。观察组患儿不良反应发生率为7%,与对照组的5%对比差异无统计学意义(P>0.05)。观察组患儿气喘消失时间、高热消失时间、咳嗽消失时间以及肺啰音消失时间分别为(3.54±0.78)、(2.52±0.85)、(7.27±0.48)、(5.55±0.82)d,均短于对照组的(4.49±0.66)、(3.69±0.34)、(8.59±0.51)、(6.79±0.57)d,差异具有统计学意义(P<0.05)。结论对支气管肺炎患儿采取乙酰半胱氨酸联合布地奈德雾化吸入治疗,可以显著缩短临床症状消失时间,改善治疗效果,具有重要的临床应用价值。

Objective To investigate the clinical efficacy of acetylcysteine combined with budesonide aerosol inhalation on children with bronchopneumonia.Methods A total of 200 children with bronchopneumonia were divided into an observation group and a control group according to the random numerical table,with 100 cases in each group.The control group received conventional treatment,and the observation group received acetylcysteine combined with budesonide aerosol inhalation on the basis of conventional treatment.The therapeutic effect,the occurrence of adverse reactions and the disappearance time of clinical symptoms were compared between the two groups.Results The total effective rate of the observation group was 99%,which was higher than that of 87%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 7%,which had no statistical significance compared with that of 5%in the control group(P>0.05).The disappearance time of asthma,high fever,cough and pulmonary rales in the observation group were(3.54±0.78),(2.52±0.85),(7.27±0.48)and(5.55±0.82)d,which were shorter than those of(4.49±0.66),(3.69±0.34),(8.59±0.51)and(6.79±0.57)d in the control group,and the differences were statistically significant(P<0.05).Conclusion Acetylcysteine combined with budesonide aerosol inhalation in children with bronchopneumonia can significantly shorten the disappearance time of clinical symptoms,improve the therapeutic effect,and has important clinical application value.