糠酸莫米松联合腺样体切除治疗对慢性鼻-鼻窦炎患儿临床症候的影响

Effect of mometasone furoate combined with adenoidectomy on clinical symptoms of children with chronic rhinosinusitis

目的探讨糠酸莫米松联合腺样体切除治疗对慢性鼻-鼻窦炎患儿临床症候的影响。方法100例慢性鼻-鼻窦炎患儿,随机分为药物联合手术治疗组和药物治疗组,每组50例。药物治疗组实施糠酸莫米松治疗,药物联合手术治疗组则在药物治疗组的基础上实施腺样体切除治疗。比较两组患儿治疗效果,不良事件发生率,治疗前后鼻窦炎症状积分、健康调查简表评分,流涕消失时间、鼻塞缓解时间、扁桃体改善时间。结果药物联合手术治疗组治疗总有效率98.00%高于药物治疗组的78.00%,差异具有统计学意义(P<0.05)。治疗后,两组鼻窦炎症状积分低于治疗前,健康调查简表评分高于治疗前,且药物联合手术治疗组鼻窦炎症状积分(0.13±0.02)分低于药物治疗组的(1.21±0.13)分,健康调查简表评分(92.19±3.67)分高于药物治疗组的(80.29±3.11)分,差异均具有统计学意义(P<0.05)。药物联合手术治疗组流涕消失时间(5.35±1.02)d、鼻塞缓解时间(5.56±1.21)d、扁桃体改善时间(4.13±0.56)d均短于药物治疗组的(7.42±2.05)、(8.78±2.85)、(7.21±1.88)d,差异具有统计学意义(P<0.05)。药物联合手术治疗组不良事件发生率8.00%与药物治疗组的10.00%比较,差异无统计学意义(P>0.05)。结论糠酸莫米松联合腺样体切除治疗慢性鼻-鼻窦炎的效果理想,可明显改善患儿临床症状。

Objective To discuss the effect of mometasone furoate combined with adenoidectomy on clinical symptoms of children with chronic rhinosinusitis.Methods A total of 100 children with chronic rhinosinusitis were randomly divided into drug combined surgical treatment group and drug treatment group,with 50 cases in each group.The drug treatment group was treated with mometasone furoate,and the drug combined surgical treatment group was treated with adenoidectomy based on the drug treatment group.Both groups were compared in terms of therapeutic effect,incidence of adverse events,scores of sinusitis symptoms and health survey summary before and after treatment,time of disappearance of runny nose,time of relief of nasal congestion,time of improvement of tonsils.Results The total effective rate of the drug combined surgical treatment group was 98.00%,which was higher than that of 78.00%of the drug treatment group,and the difference was statistically significant(P<0.05).After treatment,the score of sinusitis symptom in both groups were lower than that before treatment in this group,and the score of health survey summary was higher than that before treatment in this group;the score of sinusitis symptom of(0.13±0.02)points in the drug combined surgical treatment group was lower than that of(1.21±0.13)in the drug treatment group;the score of health survey summary of(92.19±3.67)points in the drug combined surgical treatment group was higher than that of(80.29±3.11)points in the drug treatment group;the differences were statistically significant(P<0.05).The time of disappearance of runny nose,time of relief of nasal congestion,time of improvement of tonsils in the drug combined surgical treatment group were(5.35±1.02),(5.56±1.21)and(4.13±0.56)d,which were all shorter than those of(7.42±2.05),(8.78±2.85)and(7.21±1.88)d in the drug treatment group,and the differences were statistically significant(P<0.05).The incidence of adverse events was 8.00%in the drug combined surgical treatment group and 10.00%in the drug treatment group,and the difference was not statistically significant(P>0.05).Conclusion Mometasone furoate combined with adenoidectomy has ideal effect in the treatment of chronic rhinosinusitis,and can obviously improve the clinical symptoms of patients.