基于补肾活血法对治疗慢性肾脏病的临床有效性及安全性的Meta分析

A Meta-analysis of the clinical effectiveness and safety of Bushen Huoxue method based on the treatment of chronic kidney disease

[目的]系统具体地对补肾活血法治疗慢性肾脏病的疗效以及安全性进行Meta分析。[方法]利用检索中国知网(CNKI)、维普资讯中文期刊服务平台(VIP)、万方数据库(Wanfang Data)、中国生物医学文献数据库(SinoMed)、PubMed、Web of Science数据库,以补肾活血法联合常规西医治疗组为试验组,以常规西医治疗组为对照组,并以“补肾活血”“慢性肾脏病”等相关词为检索词,以随机对照试验为检索目标,将符合纳入标准的相关研究以Cochrane Reviewer’s Handbook 5.0.1推荐的“偏倚风险评估”工具进行质量评价,并通过Revman5.4.1软件进行数据分析。[结果]在被纳入的18篇文献中,以临床总有效率、血肌酐、尿素氮、尿酸、肾小球滤过率、不良反应的严重程度作为结局指标,得出试验组的疗效均高于对照组的疗效,差异具有统计学意义(P<0.05)。[结论]补肾活血法对治疗慢性肾脏病具有疗效。

[Objective]A Meta-analysis of the efficacy and safety of tonifying kidney and promoting blood circulation in the treatment of chronic kidney disease.[Methods]By searching CNKI,VIP,Wanfang Data,SinoMed,PubMed,Web of Science databases,the kidney tonifying and blood circulation method combined with conventional Western medicine treatment was used as the test group,and the conventional Western medicine treatment group was used as the control group,and the related words such as“kidney and blood circulation”,“chronic kidney disease”were used as the search terms,and the randomized controlled trials were used as the retrieval targets.Relevant studies meeting the inclusion criteria were evaluated by the“risk of bias assessment”tool recommended by Cochrane Reviewer’s Handbook 5.0.1,and the data were analyzed by Revman 5.4.1 software.[Results]In the 18 articles included,taking the clinical efficiency,blood creatinine,urea nitrogen,uric acid,glomerular filtration rate,severity of adverse reactions as outcome indicators,it was concluded that the efficacy of the experimental group was higher than that of the control group,with statistical difference(P<0.05).[Conclusion]The method of tonifying kidney and activating blood circulation has curative effect on chronic kidney disease.