生物碱类天然药物抗痛风作用及作用机制的研究进展

Progress on the anti-gout effect and action mechanism of alkaloid natural drugs

痛风是由于机体嘌呤代谢异常和(或)尿酸排泄障碍所致的一组异质性疾病。生物碱是一类含有氮的有机化合物,广泛存在于植物中,用于痛风等多种疾病引起的炎症反应。通过查阅国内外最新相关文献报道,对生物碱抗痛风作用及作用机制的研究进展进行综述,以期为生物碱的进一步研究和临床应用提供科学依据和理论指导。

Gout is a heterogeneous group of diseases caused by abnormal purine metabolism and(or)impaired excretion of uric acid.Alkaloids are a class of organic compounds containing nitrogen that are widely found in plants and used for inflammatory reactions caused by many diseases such as gout.By consulting the latest relevant literature reports at home and abroad,this paper summarizes the research progress of the effect and mechanism of alkaloids against gout,in order to provide scientific basis and theoretical guidance for further research and clinical application of alkaloids.