经皮穴位电刺激序贯疗法对行体外受精-胚胎移植不孕患者影响分析

Analysis of the effect of sequential therapy of transcutaneous acupoint electrical stimulation on infertility patients undergoing external fertilization embryo transfer

目的探讨经皮穴位电刺激(TEAS)序贯疗法在体外受精-胚胎移植(IVF-ET)不孕患者中的应用价值。方法选取2020年1月至2021年1月本院收治的78例行IVF-ET的不孕患者作为研究对象,按照随机数字表法分为对照组与研究组,每组39例。对照组采取西药拮抗剂促排措施,研究组在对照组基础上实施TEAS序贯疗法,持续观察至移植后42 d。比较两组激素水平、窦卵泡数、胚胎发育情况及妊娠结局。结果治疗前,两组促卵泡激素(FSH)、雌二醇(E2)水平及窦卵泡数比较差异无统计学意义;治疗后,研究组FSH水平低于对照组,E2水平高于对照组,窦卵泡数多于对照组,差异有统计学意义(P<0.05)。两组受精率、卵裂率比较差异无统计学意义;研究组优胚率高于对照组,差异有统计学意义(P<0.05)。研究组生化妊娠率低于对照组,临床妊娠率高于对照组,差异有统计学意义(P<0.05)。结论TEAS序贯疗法应用于行IVF-ET不孕患者中效果更佳,可调节机体激素水平,促进窦卵泡正常发育,提高优胚率,改善妊娠结局。

Objective To explore the application value of transcutaneous electrical acupoint stimulation(TEAS)sequential therapy in infertile patients undergoing external fertilization embryo transfer(IVF-ET).Methods 78 infertile patients with IVF-ET admitted to our hospital from January 2020 to January 2021 were selected as the study subjects,they were randomly divided into the control group and the study group by the random number table method,with 39 cases in each group.The control group was treated with western drug antagonist to promote excretion,and the study group was treated with TEAS sequential therapy on the basis of the control group until 42 d after transplantation.The hormone levels,the number of sinus follicles,embryonic development and pregnancy outcome were compared between the two groups.Results Before treatment,there was no significant difference in the levels of follicle stimulating hormone(FSH),estradiol(E2)and the number of antral follicles between the two groups;after treatment,the FSH level in the study group was lower than that the control group,the E2 level was higher than the control group,and the number of sinus follicles was higher than that in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in fertilization rate and cleavage rate between the two groups;the excellent embryo rate in the research group was higher than that in the control group,and the differences were statistically significant(P<0.05).The biochemical pregnancy rate in the study group was lower than the control group,and the clinical pregnancy rate was higher than the control group,and the differences were statistically significant(P<0.05).Conclusion TEAS sequential therapy is more effective in patients undergoing IVF-ET infertility,regulating hormone levels in the body,promoting normal development of sinus follicles,increasing embryo yield,and improving pregnancy outcomes.