醋酸甲地孕酮改善晚期恶性肿瘤患者营养状况的疗效观察

Efficacy of megestrol acetate in improving nutritional status of patients with advanced malignant tumors

目的探讨醋酸甲地孕酮改善晚期恶性肿瘤患者营养状况的疗效。方法选取2018年6月至2020年6月安顺市人民医院肿瘤科收治的70例存在营养风险的晚期恶性肿瘤患者作为研究对象,按照随机数字表法分为观察组与对照组,每组35例。对照组采用对症支持治疗,观察组在对照组基础上联合醋酸甲地孕酮治疗,比较两组进食量和体质量改善情况、卡诺夫斯凯计分(KPS)评分、相关营养指标变化及不良反应发生情况。结果观察组进食量增加、体质量增加占比均高于对照组,差异有统计学意义(P<0.05)。治疗前后,两组KPS评分比较差异无统计学意义;治疗后,观察组KPS评分高于治疗前,差异有统计学意义(P<0.05),对照组治疗前后比较差异无统计学意义。治疗前,两组BMI、Alb、LC比较差异无统计学意义;治疗后,观察组Alb、LC均高于治疗前,观察组Alb高于对照组,差异有统计学意义(P<0.05),其他两两比较差异无统计学意义。两组不良反应发生率比较差异无统计学意义。结论醋酸甲地孕酮可改善晚期恶性肿瘤患者的营养状况,安全性较高,不影响患者身体状况,值得临床推广使用。

Objective To explore the efficacy of megestrol acetate in improving nutritional status of patients with advanced malignant tumors.Methods 70 patients with advanced malignant tumors with nutritional risk admitted to the oncology department of Anshun People's Hospital from June 2018 to June 2020 were selected as the study subjects,and they were divided into the observation group and the control group according to the random number table method,with 35 cases in each group.The control group was treated with symptomatic supportive treatment,and the observation group was treated with megestrol acetate on the basis of the control group,the improvement of food intake and body mass,Kanofsky performance score(KPS),changes of related nutritional indexes and occurrence of adverse reactions were compared between the two groups.Results The proportion of food intake and body mass increase in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Before and after treatment,there was no significant difference in KPS score between the two groups;after treatment,KPS score in observation group was higher than before treatment,the difference was statistically significant(P<0.05),there was no statistically significant difference in the control group before and after treatment.Before treatment,there was no significant difference in BMI,Alb and LC between the two groups;after treatment,Alb and LC in the observation group were higher than those before treatment,Alb in the observation group was higher than that in the control group,the differences were statistically significant(P<0.05),and there was no significant difference between the other two groups.There was no significant difference in the incidence of adverse reactions between the two groups.There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Megestrol acetate can improve the nutritional status of patients with advanced malignant tumors,has high safety,does not affect the physical condition of patients,and is worthy of clinical promotion and application.