雷洛昔芬对绝经期慢性精神分裂症患者的阴性症状及认知功能和生活质量的影响

Effect of Raloxifene on negative symptoms, cognitive function, and quality of life in menopausal patients with chronic schizophrenia

目的研究绝经期慢性精神分裂症患者应用雷洛昔芬对阴性症状及认知功能和生活质量的影响。方法选取安徽省芜湖市第四人民医院2021年1月至2022年1月门诊接诊的80例以阴性症状为主并长期服用氯氮平治疗的绝经后女性精神分裂症患者为研究对象。按照随机数字表法将其分为对照组(40例)与研究组(40例)。对照组给予氯氮平治疗,研究组给予氯氮平联合雷洛昔芬治疗,连续治疗12周。比较两组治疗前后的阳性与阴性症状量表(PANSS)评分、阴性症状评定量表(SANS)评分、血清雌二醇(E2)水平、重复性成套神经心理状态测验(RBANS)评分、生活质量综合评定问卷-74(GQOLI-74)评分;观察治疗期间不良反应发生情况。结果治疗后,两组SANS评分、PANSS评分较治疗前降低,且研究组低于对照组(P<0.05);E2水平较治疗前升高,且研究组高于对照组(P<0.05)。治疗后,两组即刻记忆、注意力、言语功能、延迟记忆、视觉广度评分较治疗前升高,且研究组高于对照组(P<0.05)。治疗后,两组物质生活状态、社会功能、躯体功能、心理功能评分较治疗前升高,且研究组高于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论雷洛昔芬能有效缓解绝经期慢性精神分裂症患者的阴性症状,对提高患者的生活质量与认知功能有一定的促进作用,且安全性高。

Objective To study the effect of Raloxifene on negative symptoms,cognitive function,and quality of life in menopausal patients with chronic schizophrenia.Methods A total of 80 postmenopausal female schizophrenics with negative symptoms and long-term treatment with Clozapine from the outpatient department of Wuhu Fourth People’s Hospital,Anhui Province from January 2021 to January 2022 were selected as the research object.According to random number table method,they were divided into control group(40 cases)and study group(40 cases).The control group was treated with Clozapine,and the research group was treated with Clozapine and Raloxifene,the treatment lasted for 12 weeks.The positive and negative symptom scale(PANSS)score,scale for assessment of negative symptoms(SANS)score,serum estradiol(E2)levels,the repeatable battery for the assessment of neuropsychological status(RBANS)score,and generic quality of life inventory-74(GQOLI-74)score were compared between two groups before and after treatment;the occurrence of adverse reactions during treatment was observed.Results After treatment,the SANS score and PANSS score of two groups were lower than those before treatment,and those in study group were higher than those in control group(P<0.05),and the E2 level of two groups was higher than that before treatment,and that in study group was higher than that in control group(P<0.05).After treatment,the scores of immediate memory,attention,verbal function,delayed memory,and visual span in two groups were higher than those before treatment,and those in study group were higher than those in control group(P<0.05).After treatment,the scores of material life status,social function,physical function,and psychological function of two groups were higher than those before treatment,and those in study group were higher than those in control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between two groups(P>0.05).Conclusion Raloxifene can effectively relieve the negative symptoms of menopausal patients with chronic schizophrenia,improve the quality of life and cognitive function of patients,and has high safety.