基于中医传承辅助系统探讨丁治国教授治疗甲状腺功能亢进症的用药规律

Exploration of the medication rule for the use of Ding Zhiguo in the treatment of hyperthyroidism based on traditional Chinese medicine inheritance assistance system

目的借助中医传承辅助平台(V2.5)软件探索丁治国教授治疗甲状腺功能亢进症的组方用药规律。方法收集丁治国教授于2019年7月至2020年11月在北京中医药大学东直门医院甲状腺病科门诊开具的治疗甲状腺功能亢进症的中药处方并建立数据库,运用频数统计、关联规则等进行数据挖掘,分析研究核心药物及其性味、归经、组方规律。结果筛选出符合标准的处方197张,涉及中药84味,处方中药物出现频次≥110的药物22个。药物主要归经为肝、肺经,性味分别为苦、寒。处方中出现频次≥180的药对有33对,出现频次≥185的角药有19组。演变得到核心方药6个,新方核心组合6个,新处方3个;核心处方:夏枯草、合欢花、猫爪草、柴胡、香附、龙骨、牡蛎、黄芩、桔梗、牡丹皮、首乌藤、知母、生石膏、黄芪、赤芍、丹参、蒲公英、射干、泽泻、白芍、珍珠母、酸枣仁。结论丁治国教授治疗甲状腺功能亢进症以“靥本相应论”为理论基础,善用苦寒之药改善甲状腺功能亢进症所致温热性病症,配以甘味之药调补气血阴阳,疏肝健脾、肝肺同调,标本同治。

Objective To explore the prescription and medication rule of Professor Ding Zhiguo in the treatment of hyperthyroidism with the traditional Chinese medicine inheritance assistance system(V2.5)software.Methods Traditional Chinese medicine prescriptions for the treatment of hyperthyroidism issued by Professor Ding Zhiguo in the thyroidology outpatient Department of Thyropathy Dongzhimen Hospital,Beijing University of Chinese Medicine from July 2019 to November 2020 were collected and a database was established.Frequency statistics,association rules,and so on were used for data mining to analyze and study the core drugs and their nature,flavour,channel tropism,and prescription formation laws.Results A total of 197 prescriptions meeting the criteria were screened out,involving 84 kinds of traditional Chinese medicine,and 22 drugs with frequency≥110 in the prescriptions.The main channel tropism of drugs were liver and lung channels.The nature and flavour of drugs were bitter and cold respectively.There were 33 couplet medicines with frequency≥180 and 19 groups of three medicines with frequency≥185.There were six core prescriptions,six new formula core combinations,and three new prescriptions.The core prescriptions were:Prunellae Spica,Albiziae Flos,Ranunculi Ternati Radix,Bupleuri Radix,Cyperi Rhizoma,Os Draconis,Ostreae Concha,Scutellariae Radix,Platycodonis Radix,Moutan Cortex,Polygoni Multiflori Caulis,Anemarrhenae Rhizoma,Gypsum Fibrosum,Astragali Radix,Paeoniae Radix Rubra,Salviae Miltiorrhizae Radix Et Rhizoma,Taraxaci Herba,Belamcandae Rhizoma,Alismatis Rhizoma,Paeoniae Radix Alba,Margaritifera Concha,Ziziphi Spinosae Semen.Conclusion Professor Ding Zhiguo’s treatment of hyperthyroidism is based on the theory of“Yeben Xiangying”.He is good at using bitter and cold drug to improve the warm-heat disease caused by hyperthyroidism,combined with sweet drug to regulate and tonify qi,blood,yin and yang,sooth liver and strengthen spleen,regulate liver and lung,and treat both symptoms and root causes.