摘要
目的分析多囊卵巢综合征(PCOS)患者血清微RNA(miRNA)-29a、miR-143-3p表达与肥胖、糖脂代谢和胰岛素抵抗(IR)的关系。方法选取2019年6月至2022年6月厦门大学附属中山医院(以下简称“我院”)收治的86例PCOS患者为PCOS组,另选取我院同期49名体检健康志愿者为对照组。根据体重指数(BMI)将PCOS患者分为肥胖组(36例)与非肥胖组(50例),根据稳态模型评估(HOMA)-IR分为IR组(61例)与非IR组(25例)。比较各组血清miR-29a、miR-143-3p表达,肥胖指标[BMI、腰臀比(WHR)]、糖脂代谢指标[空腹血糖(FBG)、空腹胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]及HOMA-IR;分析PCOS患者血清miR-29a、miR-143-3p表达与肥胖指标、糖脂代谢指标和HOMA-IR的相关性。结果PCOS组BMI、WHR、FBG、FINS、HOMA-IR、TC、TG、LDL-C、miR-29a、miR-143-3p高于对照组,HDL-C低于对照组(P<0.05)。肥胖组血清miR-29a、miR-143-3p表达高于非肥胖组(P<0.05)。IR组血清miR-29a、miR-143-3p表达高于非IR组(P<0.05)。PCOS患者血清miR-29a、miR-143-3p表达与BMI、WHR、FBG、FINS、HOMA-IR、TC、TG、LDL-C呈正相关(r/rs>0,P<0.01),与HDL-C呈负相关(r<0,P<0.01)。结论PCOS患者血清miR-29a、miR-143-3p高表达,与肥胖、糖脂代谢和IR密切相关。
Objective To analyze the relationship between serum microRNA(miRNA)-29a and miR-143-3p expression and obesity,glucolipid metabolism,and insulin resistance(IR)in patients with polycystic ovary syndrome(PCOS).Methods A total of 86 patients with PCOS admitted to Zhongshan Hospital Affiliated to Xiamen University(hereinafter referred to as“our hospital”)from June 2019 to June 2022 were selected as the PCOS group,and 49 healthy volunteers with physical examination in our hospital during the same period were selected as the control group.PCOS patients were divided into the obese group(36 cases)and the non-obese group(50 cases)according to body mass index(BMI),and they were divided into the IR group(61 cases)and the non-IR group(25 cases)according to homeostasis model assessment(HOMA)-IR.Serum miR-29a,miR-143-3p expression and obesity indicators(BMI,waist-to-hip ratio[WHR]),glucolipid metabolism indicators(fasting blood glucose[FBG],fasting insulin[FINS],total cholesterol[TC],triacylglycerol[TG],high-density lipoprotein cholesterol[HDL-C],and low-density lipoprotein cholesterol[LDL-C])and HOMA-IR of all groups were compared;the correlation between serum miR-29a and miR-143-3p expression and obesity indicators,glucolipid metabolism indicators,and HOMA-IR in PCOS patients were analyzed.Results BMI,WHR,FBG,FINS,HOMA-IR,TC,TG,LDL-C,miR-29a,and miR-143-3p in PCOS group were higher than those in control group,and HDL-C was lower than that in the control group(P<0.05).Serum miR-29a and miR-143-3p expression in the obese group were higher than those in the non-obese group(P<0.05).Serum miR-29a and miR-143-3p expression in the IR group were higher than those in the non-IR group(P<0.05).Serum miR-29a and miR-143-3p expression in PCOS patients were positively correlated with BMI,WHR,FBG,FINS,HOMA-IR,TC,TG,and LDL-C(r/rs>0,P<0.001)and HDL-C was negatively correlated(r<0,P<0.001).Conclusion High expression of serum miR-29a and miR-143-3p in PCOS patients is closely associated with obesity,glucose and lipid metabolism,and IR.
作者
方秀丽
王达颖
黄秀敏
晁鹏丽
佘晶蓉
魏卓华
FANG Xiuli;WANG Daying;HUANG Xiumin;CHAO Pengli;SHE Jingrong;WEI Zhuohua(Department of Obstetrics and Gynecology,Zhongshan Hospital Affiliated to Xiamen University,Fujian Province,Xiamen361004,China;Department of Clinical Laboratory,Zhongshan Hospital Affiliated to Xiamen University,Fujian Province,Xiamen361004,China;Department of Clinical Medicine,Xiamen University Medical School,Fujian Province,Xiamen361004,China)
出处
《中国医药导报》
CAS
2023年第30期108-112,共5页
China Medical Herald
基金
福建省自然科学基金资助项目(2019J01557)。