扶脾益肾汤辅助治疗脾肾阳虚型中重度慢性牙周炎的临床效果

Clinical effect of Fupi Yishen Decoction in treating moderate and severe chronic periodontitis with syndrome of yang deficiency of spleen and kidney

目的探讨扶脾益肾汤辅助治疗脾肾阳虚型中重度慢性牙周炎的临床效果。方法选取武汉市中医医院2021年4月至2022年5月收治的60例脾肾阳虚型中重度慢性牙周炎患者为研究对象,按照随机数字表法将其分为对照组(牙周基础治疗)和观察组(牙周基础治疗联合扶脾益肾汤),各30例。比较两组疗效,比较两组治疗前及治疗1个月后中医证候积分、牙周指标、炎症因子指标的差异,记录两组治疗期间不良反应发生情况。结果观察组的临床疗效优于对照组(P<0.05)。治疗1个月后,两组牙齿松动移位、龈肿、出血、咀嚼无力评分均低于治疗前,且观察组低于对照组(P<0.05)。治疗1个月后,两组牙周附着水平、菌斑指数、牙周袋深度均低于治疗前,且观察组低于对照组(P<0.05)。治疗1个月后,两组龈沟液肿瘤坏死因子-α、白细胞介素-1β、白细胞介素-6及血清C反应蛋白均低于治疗前,且观察组低于对照组(P<0.05)。两组治疗期间均未见明显的不良反应发生。结论扶脾益肾汤辅助治疗脾肾阳虚型中重度慢性牙周炎,可促进患者症状及牙周相关指标改善,降低炎症因子水平,效果显著。

Objective To investigate the clinical effect of Fupi Yishen Decoction in the treatment of moderate and severe chronic periodontitis with syndrome of yang deficiency of spleen and kidney.Methods Sixty moderate and severe chronic periodontitis patients with syndrome of yang deficiency of spleen and kidney admitted to Wuhan Hospital of Traditional Chinese Medicine from April 2021 to May 2022 were selected as the study objects,and they were divided into control group(periodontal basic treatment)and observation group(periodontal basic treatment combined with Fupi Yishen Decoction)according to random number table method,with 30 cases in each group.The effects of the two groups were compared,and the differences of traditional Chinese medicine syndrome scores,periodontal indicators,and inflammatory factor indicators between the two groups were compared before treatment and one month after treatment,and the occurrence of adverse reactions during treatment between the two groups were recorded.Results The clinical efficacy of the observation group was better than that of the control group(P<0.05).After one month of treatment,the scores of tooth loosening and displacement,gingival swelling,bleeding,and mastication weakness in two groups were lower than those before treatment,and those of observation group was lower than those of control group(P<0.05).After one month of treatment,periodontal attachment level,plaque index,and periodontal pocket depth in two groups were lower than those before treatment,and those of observation group were lower than those of control group(P<0.05).After one month of treatment,the gingival crevicular fluid tumor necrosis factor-α,interleukin-1β,interleukin-6,and serum C-reactive protein in two groups were lower than those before treatment,and those of observation group were lower than those of control group(P<0.05).No obvious adverse reactions were observed in both groups during treatment.Conclusion Fupi Yishen Decoction adjuvant treatment of moderate and severe chronic periodontitis with syndrome of yang deficiency of spleen and kidney,can promote the improvement of symptoms,and periodontal related indicators,reduce the level of inflammatory factors,the effect is significant.