Apelin-13在认知功能障碍中相关机制的研究进展

Research progress on the related mechanisms of Apelin-13 in cognitive dysfunction

Apelin是一种生物活性肽,是血管紧张素Ⅱ1型受体相关蛋白APJ的内源性配体,其前体可被蛋白酶切割为多种活性片段,其中Apelin-13与APJ的亲和力最强。Apelin-13广泛存在于中枢神经系统,通过调节细胞凋亡、细胞自噬、突触可塑性、神经炎症、氧化应激等方式发挥神经保护作用。神经元在神经系统发育和成熟过程中发挥着重要的作用,神经元受损与认知功能障碍密切相关。因此,Apelin-13介导的神经保护作用对改善各种原因导致的认知功能障碍有很大潜力。本文综述了Apelin-13在认知功能障碍的最新研究进展,有望为认知功能障碍的治疗提供新的靶点和策略。

Apelin is a bioactive peptide and an endogenous ligand for the angiotensinⅡtype one receptor-related protein APJ.Its precursor can be cleaved into various active fragments by proteases,with Apelin-13 having the strongest affinity with APJ.Apelin-13 is widely present in the central nervous system and exerts neuroprotective effects by regulating cell apoptosis,autophagy,synaptic plasticity,neuroinflammation,and oxidative stress.Neurons play an important role in the development and maturation of the nervous system,and neuronal damage is closely related to cognitive dysfunction.Therefore,the neuroprotective effect mediated by Apelin-13 has great potential for improving cognitive impairment caused by various reasons.This article reviews the latest research progress of Apelin-13 in cognitive impairment,which is expected to provide new targets and strategies for the treatment of cognitive impairment.