抗抑郁药在炎症性肠病中的应用进展

Application progress of antidepressants in inflammatory bowel disease

炎症性肠病(IBD)是一种慢性、复发性、非特异性肠道炎性疾病,其发病率逐年升高且病因不明,目前尚无治愈方法。该疾病具有反复发作及迁延不愈的特点,给患者带来了极大的心理负担,患抑郁、焦虑症的风险大大增加。近年来研究显示,抗抑郁药物可以改变IBD患者的病程,改善预后,其作用机制可能是通过脑-肠轴达到抗炎、改善微生物群结构。本文就抗抑郁药与IBD作一综述,以推动抗抑郁药在IBD中的研究。

Inflammatory bowel disease(IBD)is a chronic,recurrent,non-specific intestinal inflammatory disease.Its incidence is increasing year by year and the etiology is unknown.At present,there is no cure.The disease has characteristics of repeated attacks and prolonged,which brings great psychological burden to patients,and the risk of depression and anxiety is greatly increased.Research in recent years has shown that antidepressants can change the course of IBD patients and improve the prognosis.The mechanism of action may be to achieve anti-inflammatory and improve structure through brain-intestinal axis.This article reviews the relationship between antidepressants and IBD in order to promote the study of antidepressants in IBD.