超分子水杨酸外涂治疗玫瑰痤疮的临床效果及对炎症因子的影响

Clinical effect of supramolecular salicylic acid on acne rosacea and its influence on inflammatory factors

目的观察超分子水杨酸外涂治疗玫瑰痤疮的临床效果及对炎症因子的影响。方法选取江苏省淮安市第二人民医院收治的86例玫瑰痤疮患者为研究对象,根据随机数字表法将其分为微针组(43例)和微针+水杨酸组(43例)。两组均给予抗生素治疗,微针组在抗生素基础上加用黄金微针,微针+水杨酸组在微针组基础上加用超分子水杨酸外涂治疗。连续治疗8周,比较两组炎症因子、皮肤生理功能、症状评分及生活质量的差异,统计两组疗效和安全性。结果微针+水杨酸组在治疗过程中脱落6例,最终纳入37例。治疗后,两组经皮水分散失值、皮肤红斑指数、皮肤油脂、白细胞介素(IL)-4、IL-6、IL-37、肿瘤坏死因子-α(TNF-α)均低于治疗前,且微针+水杨酸组低于微针组,差异有统计学意义(P<0.05)。治疗后,两组角质层含水量、痤疮特异性生活质量问卷评分高于治疗前,且微针+水杨酸组高于微针组,差异有统计学意义(P<0.05)。治疗后,两组潮红、红斑、丘疹、脓疱、毛细血管扩张评分低于治疗前,且微针+水杨酸组低于微针组,差异有统计学意义(P<0.05)。微针+水杨酸组疗效优于微针组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论超分子水杨酸外涂及黄金微针治疗玫瑰痤疮可改善皮肤生理功能,抑制炎症反应,减轻症状,提高生活质量。

Objective To observe the clinical effect of supramolecular salicylic acid on acne rosacea and its influence on inflammatory factors.Methods Eighty-six patients with acne rosacea treated in the Second People’s Hospital of Huaian,Jiangsu Province were selected as the study objects,and were divided into microneedle group(43 cases)and microneedle+salicylic acid group(43 cases)according to random number table method.Both groups were treated with antibiotics,the microneedles group was treated with gold microneedles on the basis of antibiotics,and the microneedles+salicylic acid group was treated with supramolecular salicylic acid on the basis of microneedles group.After continuous treatment for eight weeks,the differences of inflammatory factors,skin physiological function,symptom score,and quality of life between the two groups were compared,and the efficacy and safety of the two groups were analyzed.Results In the microneedle+salicylic acid group,six cases fell off during treatment,and 37 cases were eventually included.After treatment,trans epidermal water loss,skin erythematous index,skin oil,interleukin(IL)-4,IL-6,IL-37,and tumor necrosis fact-α(TNF-α)in two groups were lower than those before treatment,and those of microneedles+salicylic acid group were lower than those of microneedles group,the differences were statistically significant(P<0.05).After treatment,cuticle water content and acne-specific quality of life questionnaire scores in two groups were higher than those before treatment,and those of microneedles+salicylic acid group were higher than those of microneedles group,the differences were statistically significant(P<0.05).After treatment,the scores of flushing,erythema,papule,pustules,and telangiectasia in two groups were lower than those before treatment,and those of microneedle+salicylic acid group were lower than those of microneedle group,the differences were statistically significant(P<0.05).The therapeutic effect of microneedle+salicylic acid group was better than that of microneedle group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Supramolecular salicylic acid and gold microneedles in the treatment of rosacea can improve skin physiological function,inhibit inflammatory response,alleviate symptoms,and improve quality of life.