中国PCI术后患者合并焦虑抑郁与预后相关性的Meta分析

Meta-Analysis of the Correlation Between Anxiety and Depression and Prognosis in Chinese Patients After PCI

目的通过Meta分析研究中国PCI术后患者合并焦虑抑郁与较差预后的相关性。方法计算机检索PubMed、Embase、Web of Science、中国知网、万方、中国生物医学文献数据库、维普中截至2023年2月5日发表的有关PCI术后焦虑抑郁与预后相关性的队列研究/病例对照研究,并对检索文献进行筛选、资料提取、质量评价,用STATA 16.0进行数据分析。结果共纳入11项研究,总样本量2966例,5篇队列研究的样本量1391例;6篇病例对照研究样本量1575例,并对不同研究类型进行亚组分析。Meta分析结果:术后焦虑(OR=2.301,95%CI 2.175~2.434);术后抑郁(OR=2.862,95%CI 2.142~3.824);术后焦虑抑郁(OR=1.936,95%CI 1.536~2.439)与患者PCI术后发生MACE相关,差异有统计学意义(P<0.001)。亚组分析结果显示:队列研究中的焦虑抑郁(HR=3.707,95%CI 2.133~6.442)与病例对照研究中的焦虑抑郁(OR=1.686,95%CI 1.307~2.175)与患者PCI术后发生MACE相关,差异有统计学意义(P<0.001)。结论焦虑、抑郁及焦虑抑郁都是PCI术后患者发生MACE的危险因素。为保证研究结论的可靠性,未来还需更多文献予以支撑佐证。

Objective To study the correlation between anxiety and depression and poor prognosis in Chinese patients after PCI by Meta-analysis.Methods The cohort studies/case-control studies on the correlation between anxiety and depression after PCI and prognosis published in PubMed,Embase,Web of Science,CNKI,CBM,Vip and Wanfang databases up to February 5,2023 were retrieved by computer.The retrieved documents were screened,extracted and evaluated,and the data was analyzed with STATA16.0.Results A total of 11 studies were included,with a total sample size of 2966 and a sample size of 1391 in 5 cohort studies,a sample size of 1575 in 6 case-control studies,and subgroup analysis was conducted for different types of studies.Meta-analysis results showed postoperative anxiety(OR=2.301,95%CI 2.175~2.434);Postoperative depression(OR=2.862,95%CI 2.142~3.824);Postoperative anxiety combined with depression(OR=1.936,95%CI 1.536~2.439)were associated with MACE after PCI,and the difference was statistically significant(P<0.001).The results of subgroup analysis showed:Anxiety and depression in the cohort study(HR=3.707,95%CI 2.133~6.442)and in the case-control study(OR=1.686,95%CI 1.307~2.175)were associated with MACE after PCI,and the difference was statistically significant(P<0.001).Conclusion Anxiety,depression and anxiety combined with depression are risk factors for MACE in patients after PCI.In order to ensure the reliability of the research conclusions,more literatures are needed in the future.