乳酸菌阴道胶囊治疗妊娠晚期细菌性阴道病的效果及其对阴道菌群、妊娠结局的影响

Effect of Lactobacillus Vaginal Capsules in the treatment of bacterial vaginosis in third trimester and its effect on vaginal flora and pregnancy outcome

目的分析妊娠晚期细菌性阴道病(BV)患者采用乳酸菌阴道胶囊治疗的效果及对阴道菌群、妊娠结局的影响。方法选取2020年1月至2022年12月菏泽市牡丹人民医院收治的140例妊娠晚期BV患者作为研究对象,按照随机黑白球分为对照组(70例)和观察组(70例)。对照组采用甲硝唑栓治疗,观察组采用乳酸菌阴道胶囊,比较两组的阴道乳酸菌计数情况、临床疗效及妊娠结局(早产、产褥感染、新生儿黄疸、胎膜早破)、不良反应发生情况(下腹疼痛、皮肤瘙痒、感染),观察两组治疗前后阴道酸碱度与阴道清洁度。结果观察组的临床总有效率高于对照组,观察组的乳酸菌计数正常率高于对照组,观察组的不良妊娠结局总发生率低于对照组,差异有统计学意义(P<0.05)。观察组的阴道酸碱度低于对照组,阴道清洁度正常率高于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论在妊娠晚期BV患者治疗中用乳酸菌阴道胶囊治疗能够提高疾病治疗效果,较常规药物治疗更能降低不良妊娠结局,减少阴道酸碱度,保证阴道清洁,对阴道菌群正常率的提高更有重要作用,值得临床推广应用。

Objective To analyze the effect of Lactobacillus Vaginal Capsules on vaginal flora and pregnancy outcome in patients with bacterial vaginosis(BV)in third trimester.Methods A total of 140 patients with BV in the third trimester of pregnancy treated in Heze Peony People's Hospital from January 2020 to December 2022 were selected as the study objects and divided into control group(70 cases)and observation group(70 cases)according to random black and white balls.The control group adopted conventional treatment,the observation group used Lactobacillus Vaginal Capsules.The vaginal lactobacillus count,clinical efficacy,pregnancy outcomes(preterm birth,puerperal infection,neonatal jaundice,premature rupture of membranes)and adverse reactions(lower abdominal pain,skin pruritus,infection)of the two groups were compared,and the vaginal pH and vaginal cleanliness of the two groups were observed before and after treatment.Results The total clinical effective rate of the observation group was higher than that of the control group,the normal rate of lactobacillus count in the observation group was higher than that of the control group,and the total incidence of adverse pregnancy outcome in the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).The vaginal pH in the observation group were lower than that in the control group,the normal rate of vaginal deanliness was higher than that of control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of Lactobacillus Vaginal Capsules in the third trimester BV patients can improve the treatment effect of the disease.Compared with conventional drug treatment,it can reduce the adverse pregnancy outcomes,reduce the vaginal pH,ensure vaginal cleaning,and play a more important role in the improvement of the normal rate of vaginal flora,which is worthy of clinical promotion and application.