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糖尿病性白内障患者房水和血清炎症相关因子的变化及其与糖代谢相关性研究 被引量:2

Changes of inflammatory related factors in aqueous humor and serum of patients with diabetes cataract and their correlation with glucose metabolism
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摘要 目的研究糖尿病性白内障患者房水和血清中炎症因子、糖代谢指标的变化,并探讨糖尿病性白内障患者房水和血清炎症因子与糖代谢指标的相关性。方法前瞻性选取2021年1月至2022年12月在咸阳市第一人民医院进行治疗的糖尿病性白内障患者102例作为研究组,并随机选取同期白内障患者50例作为对照组。检测并比较两组患者房水和血清中白细胞介素(IL)-1β、肿瘤坏死因子-α(TNF-α)、IL-6和IL-8水平,以及血清糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)和空腹血糖。Pearson法用于分析炎症因子与糖代谢指标的相关性。结果研究组患者房水和血清IL-1β、TNF-α、IL-6和IL-8均显著高于对照组,差异均有统计学意义(P<0.05)。研究组患者空腹血糖、HbA1c、HOMA-IR和FINS均显著高于对照组,差异均有统计学意义(P<0.05)。对照组患者房水和血清炎症因子水平与其糖代谢指标HbA1c、HOMA-IR均无显著相关(P>0.05)。研究组患者HbA1c与其房水IL-1β、TNF-α、IL-6和IL-8水平均呈正相关(r=0.623、0.539、0.482、0.467;P<0.05),并且HOMA-IR也与其房水IL-1β、TNF-α、IL-6和IL-8水平均呈正相关(r=0.656、0.585、0.444、0.472、P<0.05)。研究组患者HbA1c与其血清IL-1β、TNF-α、IL-6和IL-8水平均呈正相关(r=0.563、0.524、0.531、0.512;P<0.05),并且HOMA-IR也与其血清IL-1β、TNF-α、IL-6和IL-8水平均呈正相关(r=0.553、0.562、0.581、0.547;P<0.05)。结论糖尿病性白内障患者房水和血清中的炎症细胞因子水平高于单纯白内障患者,并且其体内糖代谢异常;糖尿病性白内障患者糖代谢指标与其房水/血清炎症细胞因子含量呈显著正相关,而在白内障患者中两者不相关。 Objective To study the changes of inflammatory factors and glucose metabolism indexes in aqueous humor and serum of diabetes cataract patients,and to explore the correlation between inflammatory factors and glucose metabolism indexes in aqueous humor and serum of diabetes cataract patients.Methods A total of 102 patients with diabetes cataract who were treated in Xianyang First People's Hospital from January 2021 to December 2022 were prospectively selected as the study group,and randomly selected 50 cataract patients in the same period as the control group.The levels of interleukin(IL)-1β,tumor necrosis factor-α(TNF-α),interleukin-6 and IL-8 in aqueous humor and serum as well as serum glycated hemoglobin(HbA1c),fasting insulin(FINS),and fasting blood glucose were detected and compared between two groups of patients.The correlation between inflammatory factors and glucose metabolism indicators was analyzed by using Pearson method.Results The levels of indoor humor and serum IL-1β,TNF-α,IL-6 and IL-8 were significantly higher than those of the control group,the differences were statistically significant(P<0.05).The levels of fasting blood glucose,HbA1c,HOMA-IR,and FINS in the study group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The levels of inflammatory factors in aqueous humor and serum of control group patients were not correlated with their glucose metabolism indicators HbA1c and HOMA-IR(P>0.05).The HbA1c of study group was positively correlated and the levels of IL-1β,TNF-α,IL-6,and IL-8 in their aqueous humor(r=0.623,0.539,0.482,0.467;P<0.05),and HOMA-IR of the study group was also positively correlated with IL-1β,TNF-α,IL-6,and IL-8 in aqueous humor(r=0.656,0.585,0.444,0.472;P<0.05).The HbA1c of the study group was positively correlated with the levels of serum IL-1β,TNF-α,IL-6,and IL-8(r=0.563,0.524,0.531,0.512;P<0.05),and HOMA-IR was also positively correlated with with the levels of serum IL-1β,TNF-α,IL-6,and IL-8(r=0.553,0.562,0.581,0.547;P<0.05).Conclusion The levels of inflammatory cytokines in aqueous and serum were higher in diabetic cataract patients than in simple cataract patients,and the glucose metabolism was positively correlated with inflammatory cytokines in aqueous/serum,but not in cataract patients.
作者 刘彦章 尹晓艳 陈悦 史瑞昕 董永孝 LIU Yan-zhang;YIN Xiao-yan;CHEN Yue(Eye Trauma Center,Xianyang First People's Hospital,Xianyang Shaanxi 712000,China;Cataract Refraction Center,Xianyang First People's Hospital,Xianyang Shaanxi 712000,China;Comprehensive Eye Disease Center,Xianyang First People's Hospital,Xianyang Shaanxi 712000,China)
出处 《临床和实验医学杂志》 2023年第21期2300-2303,共4页 Journal of Clinical and Experimental Medicine
基金 陕西省卫生科研项目(编号:2018E12)。
关键词 白内障 糖尿病 炎症因子 糖代谢 Cataract Diabetes mellitus Inflammatory factors Glucose metabolism
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