红外CO_(2)激光灸对膝关节骨关节炎患者的影响:双盲、随机、对照研究

Effects of infrared CO_(2)laser moxibustion on patients with knee osteoarthritis:a double-blind,randomized,controlled study

目的:观察10.6μm红外激光灸是否能比假激光灸更好地缓解膝骨关节炎(KOA)患者的疼痛和僵硬,改善其关节功能。方法:将178例膝关节骨关节炎患者随机分为红外CO_(2)激光灸组和假激光灸组,分别给予患者双侧犊鼻穴10.6μm红外激光灸和假激光灸治疗。两组患者均接受每次20 min,每周3次的治疗,持续4周。通过治疗前、治疗中期(2周)、治疗结束(4周)和治疗后4周的西安大略与麦克马斯特大学骨关节炎指数(WOMAC)的评分变化来评估治疗效果。受试者步行50码的完成时间为次要结果指标。结果:两组治疗前WOMAC疼痛、僵硬、功能评分比较差异无统计学意义(P>0.05)。红外CO_(2)激光灸组患者在治疗中期、治疗结束时和治疗后4周的WOMAC疼痛、僵硬和功能评分均有较大改善(P<0.05)。两组在治疗前、治疗中期和治疗后完成50码步行时间差异无统计学意义(P>0.05)。结论:与假激光灸治疗相比,红外CO_(2)激光灸治疗可显著减轻膝关节骨关节炎患者的疼痛,改善膝关节僵硬和功能。

Objective:To observe whether 10.6μm infrared laser moxibustion provides greater pain and stiffness relief and improves joint function in patients with knee osteoarthritis(KOA)compared with sham laser moxibustion.Methods:A total of 178 patients with KOA were randomly divided into a CO2 laser moxibustion group and a sham laser moxibustion group by block randomization method.Patients in the two groups received 10.6μm infrared laser moxibustion or sham laser moxibustion treatment symmetrically at bilateral Dubi(ST35),respectively.Patients in both groups received 20 min of treatment,3 times per week for 4 weeks.Treatment effects were assessed by changes in the Western Ontario and McMaster Universities osteoarthritis index(WOMAC)before treatment,at mid-treatment(2 weeks),at the end of treatment(4 weeks),and 4 weeks after treatment.Completion time for walking 50 yards was evaluated as a secondary measurement.Results:There were no statistical differences in the WOMAC scores for pain,stiffness,and function between the two groups before treatment(P>0.05).Patients in the CO2 laser moxibustion group experienced greater improvement in WOMAC pain,stiffness,and function scores at mid-treatment,the end of treatment,and 4 weeks after treatment(P<0.05).No significant inter-group difference was found at each assessment of the 50-yard walking time(P>0.05).Conclusion:Compared with the sham laser moxibustion,10.6μm laser moxibustion can significantly reduce pain and improve knee joint stiffness and function in patients with KOA.