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不同剂量下重建矩阵对定量CT椎体骨密度测量值的影响

Effect of different reconstruction matrices on vertebral bone mineral density using quantitative CT at different scanning doses
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摘要 目的:探讨不同剂量下重建矩阵对定量CT(QCT)椎体骨密度(BMD)测量值的影响。方法:使用联影uCT760 CT机,采用两种剂量水平(管电压120 kVp管电流150或30 mAs)对欧洲标准脊柱体模(ESP)和QCT校准体模进行扫描。基于原始扫描数据,分别采用512×512、768×768、1024×1024三种矩阵进行图像重建。将重建图像传输至QCT-pro工作站进行体模内各椎体(V1、V2、V3)BMD的测量,基于椎体标定值,计算测量值的相对误差(RE),采用单因素方差分析比较不同重建矩阵下椎体骨密度相对误差差异。回顾性将在本院行胸部HRCT和胸部低剂量CT(LDCT)的各45例患者纳入本研究。对所有患者的原始图像分别采用512×512和1024×1024矩阵进行图像重建,然后由两位医师分别独立进行椎体(Th_(12)和L_(1))BMD的测量并采用组内相关系数(ICC)进行一致性检验,采用配对样本t检验比较不同重建矩阵图像上测得的Th 12和L 1椎体的BMD值及两者均值的差异。结果:150和30 mAs两种剂量水平下不同重建矩阵之间ESP体模中V1、V2、V3及V平均的BMD测量值的相对误差的差异均无统计学意义(P>0.05)。相同重建矩阵两种剂量(150和30 mAs)之间V1、V2、V3及V_(平均)的BMD测量值的相对误差的差异无统计学意义(P>0.05)。两位医师测量的患者椎体BMD值的一致性较好(ICC=0.978~0.990>0.75)。不论是HRCT图像还是LDCT图像,512×512和1024×1024两种重建矩阵之间测得的T_(12)和L_(1)的BMD值及两者均值的差异均无统计学意义(P>0.05)。结论:不同重建矩阵对QCT椎体骨密度测量值无显著影响,胸部HRCT和LDCT扫描均可用于筛查骨质疏松症。 Objective:To investigate the effect of different reconstruction matrices on vertebral bone mineral density(BMD)using quantitative computed tomography(QCT)at different radiation dose.Methods:The European spine phantom(ESP)and QCT calibration phantom were scanned using two dose levels(tube voltage of 120kVp,tube current of 150 and 30mAs)at a uCT760 CT scanner(United Imaging).Then the raw imaging data were reconstructed using 512×512,768×768 and 1024×1024 matrices,respectively.The reconstructed images were transmitted to the QCT-pro workstation for BMD measurement of each vertebra.By Taking the vertebral phantom calibration values as the contrast,the relative error(RE)of the measurements was calculated,and one-way analysis of va-riance(ANOVA)was used to compare the differences in the RE of vertebral BMD under different reconstruction matrices.Forty-five patients who underwent high resolution CT(HRCT)and low dose CT(LDCT)of the thorax at our hospital were retrospectively recuited,and vertebral BMD measurements were completed on the original images reconstructed with 512×512 and 1024×1024 matrices respectively.Measurements of BMD of the completed QCT vertebrae(Th_(12) and L_(1))were then performed independently by two practitioners in parallel with a consistency test,using a paired-samples t-test to compare the differences in BMD values of Th 12 and L 1 vertebral,and average of both between the two reconstruction matrices.Results:There were no statistical differences in the relative error of BMD measurements of"ESP standard V1,V2,V3 and V average among different reconstruction matrices at 150 and 30mAs dose levels(all P>0.05).The differences in the relative errors of BMD of V1,V2,V3 and V average between 150mAs and 30mAs with the same reconstruction matrix were not statistically significant(all P>0.05).The consistency of vertebral bone density measured by both physicians was good(ICC=0.978~0.990>0.75).No statistically significant difference(P>0.05)in Th_(12)and L_(1)BMD values and average of them were found between 512×512 matrix and 1024×1024 matrix in whether in HRCT or LDCT group.Conclusion:There was no effect of different reconstruction matrices on QCT vertebral BMD measurements,and both thoracic HRCT and LDCT data could be used for opportunistic screening of osteoporosis.
作者 王旭 刘磊 刘义军 李贝贝 童小雨 陈安良 WANG Xu;LIU Lei;LIU Yi-jun(Departmentof Radiology,the First Affiliated Hospital of Dalian Medical University,Liaoning116011,China)
出处 《放射学实践》 CSCD 北大核心 2023年第12期1593-1598,共6页 Radiologic Practice
关键词 定量CT 体层摄影术 X线计算机 重建矩阵 骨密度 椎体 Quantitative CT Tomography,X-ray computed Reconstruction matrices Bone density Vertebra
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