非编码RNA在脓毒症发病中的研究进展

Research progress on immune regulation of non-coding RNA in sepsis

脓毒症是一种由细菌、病毒、真菌感染引起的全身炎症反应综合征。这种由病原微生物诱导的炎症反应可导致多器官系统衰竭,造成严重的后果。研究表明,当脓毒症发生时,一些非编码RNA如长链非编码RNA(long noncoding RNA,lncRNA)、微RNA(microRNA,miRNA)和环状RNA(circular RNA,circRNA)的表达发生了变化。这些转录产物可以通过不同的机制参与脓毒症和多器官系统衰竭的进程。正确认识非编码RNA在脓毒症发生、发展过程中的作用,对临床中脓毒症的早发现、早诊断、早治疗有重要意义。本文对这3类非编码RNA在脓毒症发生、发展过程中的作用进行综述。

Sepsis is a systemic inflammatory response syndrome caused by bacterial,viral and fungal infections.This inflammatory response induced by pathogenic microorganisms can lead to the failure of multiple organ systems,resulting in serious consequences.Studies have shown that the expression of some non-coding RNAs such as long noncoding RNA(lncRNA),microRNA(miRNA)and circular RNA(circRNA)changes during sepsis.These transcripts can participate in multiple organ system failure through different mechanisms.Correct understanding of the role of non-coding RNA in the pathogenesis of sepsis is of great significance for the early detection,diagnosis and treatment of sepsis in clinical practice.This review mainly describes the role of these three classes of non-coding RNAs in sepsis and its related complications.