液体活检技术在胰腺癌早期筛查和诊断中的应用

Application of liquid biopsy technology in early screening and diagnosis of pancreatic cancer

胰腺癌是一种临床表现隐匿、发展迅速且预后极差的消化系统肿瘤,其早期诊断和手术治疗可提高患者生存率、明显改善预后。迄今为止仍未找到一种对早期胰腺癌有足够灵敏度、特异度的肿瘤标志物来进行肿瘤筛查。近年来,越来越多的胰腺癌相关肿瘤标志物被发现和研究,液体活检已在一系列应用中显示出潜在的实用性,具有无创、无损、实时、多次的优点,在肿瘤诊治等多方面具有广泛的前景。本文就液体活检中循环肿瘤细胞、循环肿瘤DNA在胰腺癌筛查、早期诊断方面进行探讨总结,为胰腺癌临床早发现、早治疗提供参考。

Pancreatic cancer is a kind of digestive system tumor with insidious clinical manifestations,rapid development and very poor prognosis,and its early diagnosis and surgical treatment can significantly improve the survival rate and prognosis of patients.So far,no tumor marker with sufficient sensitivity and specificity for early pancreatic cancer has been found for tumor screening.In recent years,more and more pancreatic cancer-related tumor markers have been discovered and studied.Liquid biopsy has shown potential utility in a range of applications,with the advantages of non-invasive,non-destructive,real-time,multiple,and has broad prospects in many aspects of tumor diagnosis and treatment.This article discusses and summarizes the screening and early diagnosis of circulating tumor cells and circulating tumor DNA in liquid biopsy,so as to provide reference for early detection and early treatment of pancreatic cancer.