围绝经期失眠的发生机制与治疗进展

Pathogenesis and treatment progress of perimenopausal insomnia

围绝经期女性承受着工作、家庭和生活的多重压力,其健康对个人、家庭和社会具有多重意义。特别是围绝经期失眠,如无法得到正确且有效的治疗,容易引发心血管疾病、内分泌疾病和焦虑抑郁等。目前雌激素、苯二氮卓类药物和褪黑素等疗法仍存在明显不良反应,亟须新思路、新方法突破瓶颈。中医药作为我国重要资源,对围绝经期失眠具有显著疗效和优势。本文从流行病学、发病机制、现代医学疗法、中医药实践等角度探讨围绝经期失眠的研究现状,让更多的研究者、一线医师和群众关注围绝经期女性健康。

Perimenopausal women are under multiple pressures from work,family and life,while their health are significant for individuals,families,and society.If not treated correctly and effectively,perimenopausal insomnia can easily lead to cardiovascular,endocrine,anxiety and depression and other physical and mental diseases.At present,estrogen,benzodiazepines and melatonin still have significant side effects,so new ideas and methods are urgently needed.As an important resource in China,traditional Chinese medicine(TCM)has significant therapeutic effects and advantages in treating insomnia during perimenopause.Therefore,the current research status of perimenopausal insomnia from multiple perspectives,including epidemiology,pathogenesis,modern medical therapies,and the understanding and clinical practice of TCM are discussed in this review,so that more researchers,administrators,front-line physicians and the general public can pay attention to the health of perimenopausal women.