水凝胶在前列腺癌图像引导放疗中的应用进展

Application progress of hydrogels in image-guided radiotherapy for pro-state cancer

随着图像引导技术的发展,前列腺癌靶区位置的准确度得到了显著提高。准确的靶区位置是提高前列腺癌放疗输出剂量和降低危及器官毒性的前提。前列腺癌图像引导放疗(IGRT)中大部分危及器官毒性已得到有效控制,但仍存在一定的放射性直肠炎发生概率。水凝胶是一种可有效降低前列腺癌IGRT中直肠毒性的放疗辅助器械,目前水凝胶在国外应用较为普遍,但在国内应用较少。国内外相关应用综述主要内容均集中在水凝胶对直肠的保护作用上,本综述介绍了水凝胶在前列腺癌IGRT中的最新应用进展,包括联合黄金基准标志物的注入手术过程和水凝胶注入的安全性评价,同时进一步总结了水凝胶降低直肠毒性的效果。希望通过本综述为国内水凝胶的深入应用提供一定的理论参考。

With the development of image-guided technology,the accuracy of prostate cancer target location has been significantly improved.Accurate target location is a prerequisite for increasing the output dose of prostate cancer and reducing the toxicity of dangerous organs.The toxicity of most of dangerous organs in image-guided radiotherapy(IGRT)for prostate cancer has been effectively controlled,but there is still a certain probability of radiation proctitis.Hydrogel is a kind of adjuvant radiotherapy instrument that can effectively reduce the rectal toxicity of prostate cancer IGRT.Currently,hydrogel is widely used in foreign countries,but it is rarely used in China.The main contents of domestic and foreign application reviews are focused on the protective effect of hydrogels on rectum.This review introduces the latest progress in the application of hydrogels in prostate cancer IGRT,including the surgical procedure of combined gold benchmark markers and the safety evaluation of hydrogel injection.At the same time,the effect of hydrogel on reducing rectal toxicity is further summarized.It is hoped that this review will provide some theoretical reference for the further application of hydrogels in China.