奥氮平与利培酮长期维持治疗对老年慢性精神分裂症患者心功能检测结果的对照研究

A Comparative Study of Long-Term Maintenance Therapy with Olanzapine and Risperidone on Cardiac Function Testing in Elderly Patients with Chronic Schizophrenia

目的观察长期服用奥氮平和利培酮对慢性精神分裂症患者心功能的影响。方法选取2022年8月至2023年6月南京市佑安医院收治慢性精神分裂症100例,采用随机抽样法将其分成两组,各50例。对照组实施利培酮长期维持治疗,观察组则选用奥氮平长期维持治疗,对两组治疗后的心血管检查指标[脂蛋白a(Lpa)、同型半胱氨酸(HCY)、肌酸激酶(CK)、肌酸激酶的同工酶(CK-MB)、肌钙蛋白(cTnI)、肌红蛋白(MB)]进行比较;并对两组的心电图改变情况进行记录与比较;比较两组的临床治疗效果。结果治疗后,两组的Lpa、HCY、CK、CK-MB、cTnI、MB指标差异均无统计学意义(P>0.05);观察组的S-T段改变情况高于对照组,组间差异有统计学意义(P<0.05),其他心电图改变情况差异无统计学意义(P>0.05),正常率差异无统计学意义(P>0.05);观察组总有效率94.00%,对照组90.00%,两组差异无意义(P>0.05)。结论在老年慢性精神分裂症患者中应用奥氮平或利培酮长期维持治疗有积极的价值,利培酮更有利于防止心电图S-T段的改变,更适合长期使用。但临床仍应针对患者的具体情况选择最为合适的药物进行治疗,从而优化患者预后。

Objective To observe the effects of long-term use of olanzapine and risperidone on cardiac function in patients with chronic schizophrenia.Methods A total of 100 patients with chronic schizophrenia admitted to Nanjing You'an Hospital from August 2022 to June 2023 were selected and randomly divided into two groups,with 50 patients in each group.The control group received long-term maintenance treatment with risperidone,while the observation group received long-term maintenance treatment with olanzapine,Compare the cardiovascular examination indicators[lipoprotein a(Lpa),homocysteine(HCY),creatine kinase(CK),isoenzyme of creatine kinase(CK-MB),troponin(cTnI),and myoglobin(MB)]between the two groups after treatment;And record and compare the changes in electrocardiogram between the two groups;Compare the clinical treatment efficiency of the two groups.Results After treatment,there was no statistically significant difference in Lpa,HCY,CK,CK-MB,cTnI,and MB indicators between the two groups(P>0.05).The S-T segment changes in the observation group were higher than those in the control group,and there was a statistically significant difference between the groups(P<0.05).There was no statistically significant difference in other electrocardiogram changes(P>0.05),and there was no statistically significant difference in normal rate(P>0.05).The total effective rate of the observation group was 94.00%,while the control group was 90.00%,with no significant difference between the two groups(P>0.05).Conclusions Long term maintenance therapy with olanzapine or risperidone has positive value in elderly patients with chronic schizophrenia.Risperidone is more effective in preventing changes in the S-T segment of the electrocardiogram and is more suitable for long-term use.However,in clinical practice,the most suitable medication should still be selected based on the specific situation of the patient for treatment,in order to optimize the patient's prognosis.