丹红注射液联合曲美他嗪治疗不稳定型心绞痛疗效与安全的Meta分析

Efficacy and Safety of Danhong Injection Combined with Trimetazidine in the Treatment of Unstable Angina Pectoris:a Meta-analysis

目的:对丹红注射液联合曲美他嗪治疗不稳定型心绞痛(unstable angina,UA)的临床疗效与安全性进行系统性评价。方法:计算机检索知网、万方、维普、生物医学、PubMed、Embase、Cochrane Library数据库相关研究,时间从建库截至2022年10月。两名研究员独立进行文献筛选并提取文献资料,统计分析采用RevMan5.4软件。结果:检索共获得336篇文献,最终纳入18篇文献,包含1614例患者,其中对照组804例,观察组810例。丹红注射液联合曲美他嗪可显著提高UA的临床总有效率[OR=4.85,95%CI(3.51,6.71)],显著改善心电图疗效[OR=4.04,95%CI(2.38,6.88)],可减少心绞痛发作次数[MD=-1.27,95%CI(-1.82,-0.71)],缩短心绞痛持续时间[MD=-2.36,95%CI(-2.71,-2.02)],同时还可降低不良反应发生率[OR=0.39,95%CI(0.18,0.83)]。结论:丹红注射液联合曲美他嗪治疗UA的疗效更显著,安全性更好。

Objective To conduct a systematic evaluation of the clinical efficacy and safety of Danhong Injection combined with trimetazidine in the treatment of unstable angina(UA).Methods Relevant studies were searched in CNKI,Wanfang,VIP,Biomedicine,PubMed,Embase,Cochrane Library from the establishment of the database to October 2022.Two re⁃searchers independently screened literature and extracted literature data.Revman 5.4 software was used for statistical analy⁃sis.Results A total of 336 literatures were retrieved,and 18 literatures were finally included,including 1614 patients,804 patients in the control group and 810 patients in the observation group.Danhong injection combined with trimetazidine sig⁃nificantly improved the total clinical effective rate of unstable angina pectoris[OR=4.85,95%CI(3.51,6.71)],signifi⁃cantly improved the electrocardiogram efficacy[OR=4.04,95%CI(2.38,6.88)],reduced the number of angina pectoris attacks[MD=-1.27,95%CI(-1.82,-0.71)],shortened the duration of angina pectoris[MD=-2.36,95%CI(-2.71,-2.02)],and also reduced the incidence of adverse reactions[OR=0.39,95%CI(0.18,0.83)].Conclusion Dan⁃hong injection combined with trimetazidine has more significant efficacy and better safety in the treatment of UA.