基于白蛋白透析的非生物型人工肝支持系统研究进展

Advances in non-biological artificial liver support system based on albumin dialysis

人工肝支持系统是指使用体外循环泵,通过非生物或生物的血液净化方式,暂时性部分或完全替代肝脏的功能,为肝移植的“桥接治疗”手段。人工肝支持系统能清除肝衰竭患者体内产生的各种代谢毒物,维持内环境稳态,甚至促进肝细胞再生,是临床救治急性肝衰竭的新策略。本文综述白蛋白透析的非生物人工肝支持系统的研究进展,并展望其未来的发展方向。

Artificial liver support system refers to the use of extracorporeal circulation pumps to temporarily partially or completely replace the function of the liver through non-biological or biological blood purification methods,and is a“bridge treatment”means of liver transplantation.The artificial liver support system can remove various metabolic toxins produced in patients with liver failure,maintain homeostasis of the internal environment,and even promote hepatocyte regeneration.It is a new strategy for the clinical treatment of acute liver failure.This article reviews the research progress of non-biological artificial liver support systems based on albumin dialysis and looks forward to further development directions in the future.