小檗碱对大肠埃希菌的抗菌作用及其药理机制研究进展

Research Progress in the Antibacterial Effect of Berberine on Escherichia Coli and Its Pharmacological Mechanism

小檗碱是一种具有广泛药理作用的药物,其对细菌、真菌、病毒均具有较强的药理活性,临床上主要将其用于肠道感染。其中,研究人员在研究小檗碱对大肠埃希菌的药理作用时发现,小檗碱对体内外的大肠埃希菌均具有较强的抗菌作用,而其机制可能与干扰细菌的核酸代谢、糖代谢等有关;此外,小檗碱还可以通过干扰耐药大肠埃希菌外排系统,增强其他抗菌药物的抗菌作用。该文综述和分析了小檗碱对大肠埃希菌的抗菌作用及其药理机制,为小檗碱的进一步临床研究提供参考。

Berberine is a medicine with a wide range of pharmacological effects.It has strong pharmacological activity against bacteria,fungi and viruses.Clinically,it is mainly used for intestinal infections.Researchers have found that berberine has a strong antibacterial effect on Escherichia coli both in vivo and in vitro when they studied its pharmacological effect on Escherichia coli,and its mechanism is possibly related to the interference with the nucleic acid metabolism and glucose metabolism of bacteria;in addition,berberine can enhance the antibacterial effect of other antibacterial drugs by interfering with the efflux system of drug-resistant Escherichia coli.In this article,the antibacterial effect of berberine on Escherichia coli and its pharmacological mechanism are reviewed and analyzed,to provide a reference for further clinical studies on berberine.