摘要
支链氨基酸是一类人体无法合成、主要靠外源性摄入的必需氨基酸。循环血液中支链氨基酸水平与胰岛素抵抗密切相关,其中哺乳动物雷帕霉素靶蛋白复合物1通路激活是支链氨基酸调控胰岛素抵抗的关键途径。本文就支链氨基酸的代谢过程及其在胰岛素抵抗形成中的作用和调控机制进行综述。
Branched-chain amino acids are a type of essential amino acids that the human body cannot synthesize thus mainly relying on exogenous intake.The level of branched-chain amino acids in the circulating blood is closely related to insulin resistance,and the activation of mammalian rapamycin target protein complex 1 pathway is a key pathway for branched-chain amino acids to regulate insulin resistance.This article reviews the metabolic process of branched-chain amino acids and their roles and regulatory mechanisms in insulin resistance.
作者
董瀚文
卢环宇
张皓琪
李天乐
畅正阳
栾百婷
骆文静
王建钰
薛冲
DONG Hanwen;LU Huanyu;ZHANG Haoqi;LI Tianle;CHANG Zhengyang;LUAN Baiting;LUO Wenjing;WANG Jianyu;XUE Chong(The 15th Team of the 4th Battalion,Cadet Corps,Basic Medical College,Fourth Military Medical University,Xi'an 710032,shaanxi,China;Department of Occupational and Environmental Health,Fourth Military Medical University,Xi'an 710032,shaanxi,China;the 7th Team of the 2nd Battalion,Cadet Corps,Basic Medical College,Fourth Military Medical University,Xi'an 710032,shaanxi,China;the 6th Team of the 2nd Battalion,Cadet Corps,Basic Medical College,Fourth Military Medical University,Xi'an 710032,shaanxi,China;the 12th Team of the 3rd Battalion,Cadet Corps,Basic Medical College,Fourth Military Medical University,Xi'an 710032,shaanxi,China;Department of Radiation Protection Medicine,Fourth Military Medical University,Xi'an 710032,shaanxi,China)
出处
《中南医学科学杂志》
CAS
2023年第6期970-973,共4页
Medical Science Journal of Central South China
基金
国家自然科学基金(82103789)。
关键词
支链氨基酸
胰岛素抵抗
肥胖
2型糖尿病
代谢
branched-chain amino acids
insulin resistance
obesity
type 2 diabetes
metabolism
