摘要
哮喘是一种慢性炎症性疾病,根据不同炎症细胞类型分为Th2型和非Th2型。非Th2型哮喘的特征是类固醇激素抵抗,以中性粒细胞性哮喘为主。高迁移率族蛋白1(HMGB1)是一种属于警报素家族的染色质结合蛋白,作为促炎介质参与急性和慢性免疫疾病的发生发展,是非Th2型哮喘生物标志物。本文综述HMGB1调控IL-17分泌与中性粒细胞性哮喘的关系。
Asthma is a chronic inflammatory disease,dividing into Th2 and non-Th2 types according to different inflammatory cell types.Non-Th2 asthma is characterized by steroid hormone resistance and dominated by neutrophilic asthma.High mobility group box 1(HMGB1)is a chromatin binding protein belonging to the alertin family,which is involved in the occurrence and development of acute and chronic immune diseases as a pro-inflammatory mediator and a biomarker of non-Th2 asthma.This paper reviews the relationship between the regulation of IL-17 secretion by HMGB1 in neutrophilic asthma.
作者
王慧虹
张秀峰
WANG Huihong;ZHANG Xiufeng(The Second Affiliated Hospital of Hainan Medical University,Haikou 570145,Hainan,China)
出处
《中南医学科学杂志》
CAS
2023年第6期978-981,共4页
Medical Science Journal of Central South China
基金
国家自然科学基金项目(81960006)。
