龟鹿二仙汤联合激素治疗肾虚血瘀型卵巢早衰临床研究

Clinical Study on Guilu Erxian Decoction Combined with Hormones in the Treatment of Premature Ovarian Failure with Kidney Deficiency and Blood Stasis Type

目的探究龟鹿二仙汤联合西药常规激素治疗对肾虚血瘀型卵巢早衰(premature ovarian failure,POF)患者中医证候积分及性激素水平的影响。方法选取2020年1月—2022年12月本院收治的肾虚血瘀型POF患者61例作为研究对象,根据随机数字表法分为治疗组和对照组。32例治疗组患者予以龟鹿二仙汤加减联合西药常规激素治疗,29例对照组患者予以西药常规激素治疗。比较2组患者治疗前后中医证候积分及血清卵泡刺激素(follicle-stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、雌二醇(estradiol,E_(2))水平。结果治疗后,治疗组各项中医证候积分明显低于对照组(P<0.05)。治疗组FSH、LH水平明显低于对照组(P<0.05),治疗组E_(2)水平明显高于对照组(P<0.05)。结论龟鹿二仙汤联合西药常规激素治疗能够缓解肾虚血瘀型POF患者临床症状,有效调节患者性激素水平。

Objective To investigate the effect of Guilu Erxian decoction combined with conventional Western medicine hormone therapy on traditional Chinese medicine(TCM)syndrome scores and sex hormone levels in premature ovarian failure(POF)patients with kidney deficiency and blood stasis type.Methods Sixty-one POF patients with kidney deficiency and blood stasis type admitted to our hospital from January 2020 to December 2022 were selected as the research subjects,and were randomly divided into treatment group and control group according to the random number table method.Thirty-two patients in the treatment group were treated with modified Guilu Erxian decoction combined with conventional Western medicine hormone therapy,while 29 patients in the control group were treated with conventional Western medicine hormone therapy.The TCM syndrome scores and serum levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),and estradiol(E_(2))between two groups of patients were compared before and after treatment.Results After treatment,the scores of various TCM syndromes in the treatment group were significantly lower than those in the control group(P<0.05).The levels of FSH and LH in the treatment group were significantly lower than those in the control group(P<0.05),and the E_(2)levels in the treatment group were significantly higher than those in the control group(P<0.05).Conclusion Guilu Erxian decoction combined with conventional Western medicine hormone therapy could alleviate the clinical symptoms of POF patients with kidney deficiency and blood stasis,and effectively regulate the patient's sex hormone levels.