非小细胞肺癌CT影像特征与Ki-67、血管内皮生长因子表达的关系

Relationship between CT imaging features of non-small cell lung cancer and expression of Ki-67 and vascular endothelial growth factor

目的 分析非小细胞肺癌(NSCLC)CT影像特征与Ki-67、血管内皮生长因子(VEGF)的表达关系,为NSCLC的临床诊治及判断预后提供理论依据。方法 回顾性收集我院2018年1月~2023年1月112例确诊为NSCLC的患者,采用Philips Brilliance 256iCT检查患者CT影像特征,检测NSCLC组织中Ki-67、VEGF的表达,分析影像特征、临床资料(病理类型、性别、年龄、吸烟史)与Ki-67、VEGF表达水平的关系。结果 CT特征与Ki-67表达关系中,出现毛刺征、深分叶征、动脉期强化CT值≥20 Hu、静脉期强化CT值≥20 Hu、肺门淋巴结肿大、直径≥3 cm,Ki-67阳性表达率高(P<0.05);出现钙化、胸膜牵拉征,Ki-67阳性表达率低(P<0.05);其余指标差异无统计学意义(P>0.05)。CT特征与VERF表达关系中,出现血管集束征、动脉期明显强化≥20Hu、直径≥3 cm、肺门淋巴结肿大,VEGF阳性表达率高(P<0.05);出现空泡征、深分叶征、直径<3 cm,VEGF阳性表达率低(P<0.05)。临床资料与Ki-67、VEGF表达关系中,男性、有吸烟史、患者中Ki-67阳性表达率高,病理类型为鳞癌Ki-67阳性表达率低,差异有统计学意义(P<0.05);VEGF表达与临床资料组间差异均无统计学意义(P>0.05)。结论 NSCLC患者的CT影像特征与Ki-67、VEGF中的表达状态密切相关,一定程度上可推测免疫组化指标表达情况。

Objective To explore the relationship between CT imaging features of non-small cell lung cancer(NSCLC)and the expression of Ki-67 and vascular endothelial growth factor(VEGF),providing a theoretical basis for the clinical diagnosis,treatment,and prognosis of NSCLC.Methods A retrospective analysis of 112 patients diagnosed with NSCLC in our hospital from January 2018 to January 2023.Philips Brilliance 256iCT was used to examine CT imaging features,and the expression of Ki-67 and VEGF in NSCLC tissues was detected.The relationship between imaging features,clinical data(pathological type,gender,age,smoking history),Ki-67 and VEGF expression levels was analyzed.Results In the relationship between CT features and Ki-67 expression,the presence of spiculation sign,deep lobulation sign,arterial phase enhancement CT value≥20 Hu,venous phase enhancement CT value≥20 Hu,enlargement of mediastinal lymph nodes and diameter≥3 cm was associated with a high Ki-67 positive expression rate(P<0.05).The presence of calcification and pleural traction sign was associated with a low Ki-67 positive expression rate(P<0.05).Other indicators showed no statistical significance.In the relationship between CT features and VEGF expression,the presence of vessel convergence sign,significant enhancement in the arterial phase≥20 Hu,diameter≥3 cm,and enlargement of mediastinal lymph nodes was associated with a high VEGF positive expression rate(P<0.05).The presence of air bronchogram sign,deep lobulation sign,and diameter<3 cm was associated with a low VEGF positive expression rate(P<0.05).In the relationship between clinical data and Ki-67 and VEGF expression,males,those with a smoking history,and a high Ki-67 positive expression rate in patients,and a low Ki-67 positive expression rate in squamous cell carcinoma,were statistically significant(P<0.05).There was no statistical difference in VEGF expression between different clinical data groups(P>0.05).Conclusion CT imaging features in NSCLC patients are closely related to the expression of Ki-67 and VEGF,providing a certain predictive value for immunohistochemical marker expression.