2型糖尿病合并脑梗死患者血清炎症因子的表达及与颈动脉内膜厚度的相关性

Study on expression levels of inflammatory factors in serum of patients with type 2 diabetes mellitus complicated with cerebral infarction and their correlation with carotid intimal thickness

目的探讨2型糖尿病合并脑梗死患者血清炎症因子的表达及相关性。方法选取2022年1月—2022年10月在南京医科大学附属脑科医院就诊的大于65岁老年患者且诊断为脑梗死的患者,并根据是否合并2型糖尿病将患者分为两组。搜集患者年龄、性别等临床资料,生化指标、颈动脉内膜中层厚度以及相关炎症指标。分析各种因素与2型糖尿病合并脑梗死之间的关系。结果2型糖尿病合并脑梗死组的白介素(IL)-6、IL-17、肿瘤坏死因子(TNF)-α、干扰素(INF)-γ的水平均高于单纯脑梗死,IL-10的水平则低于单纯脑梗死组,差异均有统计学意义(均P<0.05)。两组促炎因子IL-6、IL-17的表达水平与颈动脉内膜中层厚度(IMT)呈正相关,而抑炎因子IL-10的水平则与IMT呈负相关,且2型糖尿病合并脑梗死组的部分促炎因子、抑炎因子与IMT的相关性则高于单纯脑梗死组。结论相较于单纯脑梗死组,2型糖尿病合并脑梗死组患者促炎因子IL-6、IL-17的水平均升高,是该病相关的危险因素,而2型糖尿病合并脑梗死患者的抑炎因子IL-10水平降低,可能是该病有关的保护因素,临床上应该对这些指标予以检测及控制。

Objective To investigate the expression level and correlation of serum inflammatory cytokines in elderly patients with type 2 diabetes mellitus complicated with cerebral infarction.Methods Elderly patients over 65 years old who were diagnosed with cerebral infarction in the Affiliated Brain Hospital of Nanjing Medical University from January 2022 to October 2022 were enrolled,and the patients were divided into two groups according to whether they had type 2 diabetes.The age,gender and other clinical data of patients,biochemical indicators,arterial intima-media thickness and related inflammatory indicators were collected to analyze the relationship between various factors and type 2 diabetes complicated with cerebral infarction.Results The levels of interleukin-6(IL-6),IL-17,tumor necrosis factor-α(TNF-α)and interferon-γ(IFN-γ)in type 2 diabetes mellitus complicated with cerebral infarction were higher than those in simple cerebral infarction group,while the level of IL-10 were lower than that in simple cerebral infarction group,and the differences were statistically significant(all P<0.05).The expression levels of pro-inflammatory factors IL-6 and IL-17 were positively correlated with carotid intima-media thickness(IMT),while the levels of anti-inflammatory factor IL-10 were negatively correlated with IMT,and the correlation between some pro-inflammatory factors,anti-inflammatory factors and IMT was higher in type 2 diabetes patients complicated with cerebral infarction than that in the simple cerebral infarction group.Conclusions Compared with the simple cerebral infarction group,the levels of pro-inflammatory cytokines IL-6 and IL-17 in type 2 diabetes patients with cerebral infarction are increased,which are risk factors associated with this disease,while the level of anti-inflammatory factor IL-10 in type 2 diabetes patients with cerebral infarction is decreased,which may be the protective factor related to this disease.These indicators should be detected and controlled clinically.