小儿肺热咳喘颗粒联合头孢呋辛钠治疗支气管肺炎患儿的效果

Effects of Xiaoer Feire Kechuan granules combined with Cefuroxime sodium in treatment of children with bronchopneumonia

目的:观察小儿肺热咳喘颗粒联合头孢呋辛钠治疗支气管肺炎患儿的效果。方法:选取2021年1月至2022年12月该院收治的72例支气管肺炎患儿进行前瞻性研究,按随机数字表法将其分为对照组与观察组各36例。对照组采用注射用头孢呋辛钠治疗,观察组在对照组基础上联合小儿肺热咳喘颗粒治疗,比较两组临床疗效、症状消失时间、住院时间、治疗前后炎性因子[白细胞介素-6(IL-6)、淀粉样蛋白A(SAA)、降钙素原(PCT)]水平、肺功能指标[最大通气量(MVV)、用力肺活量(FVC)、呼气流量峰值(PEF)]水平和不良反应发生率。结果:观察组治疗总有效率为97.22%(35/36),高于对照组的77.78%(28/36),差异有统计学意义(P<0.05);观察组发热、气促、咳嗽、细湿啰音等症状消失时间以及住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组IL-6、SAA、PCT水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组MVV、FVC、PEF水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:小儿肺热咳喘颗粒联合头孢呋辛钠治疗支气管肺炎患儿可提高治疗总有效率和肺功能指标水平,缩短症状消失时间和住院时间,降低炎性因子水平,其效果优于单纯头孢呋辛钠治疗。

Objective:To observe effects of Xiaoer Feire Kechuan granules combined with Cefuroxime sodium in treatment of children with bronchopneumonia.Methods:A prospective study was conducted on 72 children with bronchopneumonia admitted to the hospital from January 2021 to December 2022.They were divided into control group and observation group according to the random number table method,36 cases in each group.The control group was treated with Cefuroxime sodium for injection,while the observation group was treated with Xiaoer Feire Kechuan granules on the basis of that of the control group.The clinical efficacy,the symptom disappearance time,the hospitalization time,the inflammatory factors[interleukin-6(IL-6),amyloid A(SAA),procalcitonin(PCT)]levels before and after the treatment,the pulmonary function indexes[maximum ventilation volume(MVV),forced vital capacity(FVC),peak expiratoryflow(PEF)]levels,and the incidence of adverse reactions were compared.Results:The total effective rate of the observation group was 97.22%(35/36),which was higher than 77.78%(28/36)of the control group,and the difference was statistically significant(P<0.05).The disappearance time of fever,shortness of breath,cough,fine wet rales and the hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,SAA and PCT in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of MVV,FVC and PEF in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Xiaoer Feire Kechuan granules combined with Cefuroxime sodium in the treatment of the children with bronchopneumonia can improve the total effective rate of treatment and the levels of lung function indexes,shorten the symptom disappearance time and the hospitalization time,and reduce the levels of inflammatory factors.Moreover,it is superior to single Cefuroxime sodium treatment.