摘要
该综述重点阐述了mitoNEET的结构特点及其作为调节线粒体功能的关键蛋白在调节线粒体功能、维持细胞铁稳态、参与能量代谢等方面的多种生物学功能,以期为防治与炎症、氧化应激损伤及脂质代谢紊乱等密切相关的疾病,如肥胖、糖尿病及动脉粥样硬化相关性疾病等提供新的干预手段及治疗靶点。
This review focuses on the structural characteristics of mitoNEET and its various biological functions as a key protein in regulating mitochondrial function,maintaining cellular iron homeostasis,and participating in energy metabolism.The aim is to provide new intervention methods and therapeutic targets for the prevention and treatment of diseases closely related to inflammation,oxidative stress damage,lipid metabolism disorders,such as obesity diabetes and atherosclerosis-related diseases.
作者
郭芊芊
周楷杰
雷家骅
石富文
彭娟
熊文昊
姜志胜
GUO Qianqian;ZHOU Kaijie;LEI Jiahua;SHI Fuwen;PENG Juan;XIONG Wenhao;JIANG Zhisheng(Institute of Cardiovascular Disease,University of South China&Key Laboratory for Arteriosclerology of Hunan Province&Human International Scientific and Technological Cooperation Base of Arteriosclerotic Disease,Hengyang,Hunan 421001,China;Hengyang Medical College of University of South China,Hengyang,Hunan 421001,China)
出处
《中国动脉硬化杂志》
CAS
2023年第12期1079-1083,共5页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(81670429、91839103)
湖南省自然科学基金项目(2021JJ30021)
湖南省教育厅优秀青年项目(20B501)
湖南省大学生创新创业训练计划项目(S202310555202)。
