线粒体质量控制系统在中枢神经系统疾病中的研究进展

Research progress of mitochondrial quality control system in central nervous system diseases

线粒体质量控制(mitoQC)是指线粒体通过不间断的生物发生、动力学(分裂/融合)、自噬、有丝分裂和转运之间的动态协调循环过程。mitoQC正在成为中枢神经系统(CNS)稳态的核心调控者。线粒体作为神经元的“能源工厂”,是神经元新陈代谢和保持稳态最重要的细胞器之一,维持线粒体活性和功能完整性对神经元健康至关重要。神经元死亡和功能缺陷是造成CNS疾病患者神经功能障碍的重要原因。现重点探讨mitoQC紊乱与CNS疾病之间的内在联系,旨在对维持和/或恢复神经元线粒体稳态及其相关细胞生命过程的研究机制进行综述。

Mitochondrial quality control(mitoQC)refers to the dynamic coordinated cycling of mitochondria through uninterrupted biogenesis,dynamics(fission/fusion),autophagy,mitocytosis and translocation.MitoQC is becoming the core regulator of central nervous system(CNS)homeostasis.As the"powerhouse"of neurons,mitochondria is one of the most important organelles for neuron metabolism and homeostasis.Maintaining the activity and functional integrity of mitochondria is very important to the health of neurons.It is well known that neuronal death and functional defects are important causes of neurological dysfunction in patients with CNS diseases.This article focused on the internal relationship between mitoQC disorder and CNS diseases.The study was aimed to briefly review the research mechanisms of maintaining and/or restoring neuronal mitochondrial homeostasis and its related cellular life processes.