依托咪酯联合舒芬太尼、丙泊酚用于无痛胃肠镜检查的麻醉效果及对患者认知功能的影响

Anesthetic Effect of Etomidate Combined with Sufentanil and Propofol for Painless Gastroenteroscopy and Its Influence on Cognitive Function of Patients

目的:探讨依托咪酯联合舒芬太尼、丙泊酚用于无痛胃肠镜检查的麻醉效果及对患者认知功能的影响。方法:随机从抚州市立医院行无痛胃肠镜检查的患者中抽出80例,时间为2022年1—12月,采用随机数字表法将患者分为对照组(n=40)、试验组(n=40),并分别接受舒芬太尼+丙泊酚麻醉,依托咪酯联合舒芬太尼、丙泊酚麻醉。对两组患者的临床指标、麻醉效果、认知功能及不良反应发生情况进行比较。结果:相较于对照组,试验组麻醉起效后10 min和术后30 min的收缩压、舒张压、心率及血氧饱和度均明显更高,差异均有统计学意义(P<0.05);相较于对照组,试验组麻醉起效时间、苏醒时间及定向力恢复时间均更短,差异均有统计学意义(P<0.05);相较于对照组,试验组苏醒后15、30 min的认知功能评分均明显更高,差异均有统计学意义(P<0.05);相较于对照组(22.50%),试验组不良反应发生率(5.00%)明显更低,差异有统计学意义(P<0.05)。结论:依托咪酯联合舒芬太尼、丙泊酚用于无痛胃肠镜检查的麻醉效果显著,有助于患者生命体征的稳定,且对患者认知功能的影响较小,能够降低不良反应的发生风险。

Objective:To investigate the anesthetic effect of Etomidate combined with Sufentanil and Propofol for painless gastroenteroscopy and its influence on cognitive function of patients.Method:A total of 80 patients who underwent painless gastroenteroscopy in Fuzhou Municipal Hospital were randomly selected from January to December 2022.The patients were divided into control group(n=40)and experimental group(n=40)according to random number table method,and respectively received Sufentanil+Propofol anesthesia,Etomidate combined with Sufentanil and Propofol anesthesia.The clinical indexes,anesthetic effect,cognitive function,the occurrence of adverse reactions were compared between the two groups.Result:Compared with the control group,systolic blood pressure,diastolic blood pressure,heart rate and oxygen saturation of blood in experimental group were significantly higher 10 min after anesthesia take effect and 30 min after surgery,the differences were statistically significant(P<0.05).Compared with the control group,anesthesia take effect time,recovery time and orientation recovery time of experimental group were shorter,the differences were statistically significant(P<0.05).Compared with the control group,the cognitive function scores of experimental group were significantly higher at 15 and 30 min after recovery,the differences were statistically significant(P<0.05).Compared with the control group(22.50%),the incidence of adverse reactions in experimental group(5.00%)was significantly lower,the difference was statistically significant(P<0.05).Conclusion:Etomidate combined with Sufentanil and Propofol for painless gastroenteroscopy has a significant anesthetic effect,which is conducive to the stability of patients'vital sign,and has little impact on patients'cognitive function,which can reduce the risk of adverse reactions.