FGF19亚家族在冠心病中的研究进展

Research progress of fibroblast growth factor19 subfamily in coronary heart disease

成纤维细胞生长因子(FGFs)是一类广泛存在于生物体内,与调节胆汁酸、糖代谢和脂代谢、维生素D及体内磷的平衡密切相关,以旁分泌或内分泌方式调节多种生理病理过程的生长因子,近些年来发现其中的FGF19亚家族,一类代谢调节因子,包括FGF21、FGF23、FGF19,参与调节胆汁酸、糖代谢和脂代谢、维生素D及体内磷的平衡,对于调控心血管疾病如冠心病发挥着重要的作用。这为冠心病的临床治疗提供了新的途径。

Fibroblast growth factors(FGFs)are a kind of growth factors that widely exist in organisms and are closely related to regulating the balance of bile acid,glucose and lipid metabolism,vitamin D and phosphorus in vivo.They regulate a variety of physiological and pathological processes by paracrine or endocrine pathways.In recent years,FGF19 subfamily,a kind of metabolic regulatory factors,including FGF21,FGF23 and FGF19,participate in regulating the balance of bile acid,glucose and lipid metabolism,vitamin D and phosphorus in vivo and play an important role in regulating cardiovascular diseases such as coronary heart disease.It provides new ideas and methods for clinical treatment of coronary heart disease.