代谢综合征患者血尿酸水平与骨密度关系的探讨

Relationship between serum uric acid level and bone density in patients with metabolic syndrome

高尿酸血症与代谢性疾病密切相关。随着代谢综合征病情的进展,其可改变患者体内的机械负荷、激素及生化特征,从而对骨骼健康产生复杂影响。虽然增加的机械负荷和某些激素的产生可以预防骨质疏松,但其在体内具有促炎症和促氧化的作用,可能不利于骨骼健康,而尿酸可能具有抗氧化作用而保护骨骼。因此当代谢综合征患者体内尿酸增高时对骨骼的影响尚不能明确,本文将就此进一步探讨。

Hyperuricemia is closely related to metabolic diseases.With the development of metabolic syndrome(MS),it can change the mechanical load,hormone and biochemical characteristics of patients,thus perform a complex impact on bone health.Although the increased mechanical load and the production of some hormones can prevent osteoporosis,it can promote inflammation and oxidation in vivo,which may be harmful to bone health,and uric acid may have antioxidant effect to protect bone.Therefore,the influence of increased uric acid on bone in MS patients is still unclear.The present article will further explore this issue.