德谷门冬双胰岛素注射液治疗口服降糖药物血糖控制不佳2型糖尿病患者的效果及安全性观察

Efficacy and safety of insulin degludec and insulin aspart injection in the treatment of type 2 diabetes mellitus patients with poor blood glucose control by oral hypoglycemic drugs

目的 探讨德谷门冬双胰岛素注射液在口服降糖药物血糖控制不佳2型糖尿病(T2DM)患者中的疗效及安全性,为临床提供参考。方法 选取2020年6月至2022年8月太仓市第一人民医院收治的50例口服降糖药物血糖控制不佳T2DM患者为研究对象,按照随机数字表法分为研究组和对照组,各25例。研究组患者给予德谷门冬双胰岛素注射液治疗,对照组患者给予门冬胰岛素30注射液治疗。比较两组患者临床疗效、糖代谢指标[空腹血糖(FPG)、餐后2 h血糖(2 hPG)及糖化血红蛋白(HbA1c)]水平及低血糖发生情况。结果 两组患者整体疗效和总有效率比较,差异无统计学意义(P>0.05)。治疗后,两组患者FPG、2 hPG及HbA1c水平均较治疗前降低(P<0.05),但两组患者间FPG、2 hPG及HbA1c水平比较,差异无统计学意义(P>0.05)。研究组患者低血糖发生率低于对照组(P<0.05)。结论 在口服降糖药物血糖控制不佳的T2DM患者治疗中,应用德谷门冬双胰岛素注射液和门冬胰岛素30注射液的疗效相当,均能够有效控制血糖,且前者的低血糖发生风险较低,用药安全性较高。

Objective To investigate the efficacy and safety of insulin degludec and insulin aspart injection in type 2 diabetes mellitus(T2DM)patients with poor blood glucose control by oral hypoglycemic drugs,and to provide clinical reference.Methods 50 T2DM patients with poor blood glucose control by oral hypoglycemic drugs admitted to the First People’s Hospital of Taicang from June 2020 to August 2022 were selected as the study objects,and were divided into study group and control group according to random number table method,with 25 cases in each group.The patients in the study group were treated with insulin degludec and insulin aspart injection,and the patients in the control group were treated with insulin aspart 30 injection.The clinical efficacy,glucose metabolism indices[fasting plasma glucose(FPG),2-hour postprandial blood glucose(2 hPG)and glycosylated hemoglobin(HbA1c)]and the incidence hypoglycemia were compared between the two groups.Results There was no significant difference in overall efficacy and total effective rate between the two groups(P>0.05).After treatment,the levels of FPG,2 hPG and HbA1c in two groups were decreased compared to those before treatment(P<0.05),and there was no significant difference in the levels of FPG,2 hPG and HbA1c between the two groups(P>0.05).The total incidence of hypoglycemia in the study group was lower than that in the control group(P<0.05).Conclusion In the treatment of T2DM patients with poor blood glucose control by oral hypoglycemic drugs,insulin degludec and insulin aspart injection and insulin aspart 30 injection have similar efficacy,and both can effectively control blood glucose,and the former has a lower risk of hypoglycemia and higher drug safety.