拉贝洛尔联合硝苯地平治疗妊娠期高血压对孕妇血液流变学、睡眠质量及妊娠结局影响

Effects of labetalol combined with nifedipine for treating pregnant women with gestational hypertension on their hemorheology,sleep quality,and pregnancy outcomes

目的:探讨拉贝洛尔联合硝苯地平治疗妊娠期高血压(HDCP)效果及对孕妇睡眠质量、血液流变学、妊娠结局影响。方法:选取本院2021年1月-2022年6月收治的HDCP患者112例,随机数字表法分为观察组(56例,采用拉贝洛尔联合硝苯地平治疗)和对照组(56例,采用硝苯地平治疗)。观察两组治疗前后血压变化、血清炎性因子水平、血液流变学、睡眠质量及妊娠结局。结果:治疗2周后,观察组血压低于对照组,血hs-CRP、TNF-α、IL-12均低于对照组,血浆黏度(1.31±0.33 mPa/S)、全血低剪切黏度(6.57±0.17 mPa/S)、全血高剪切黏度(3.23±1.13 mPa/S)水平均低于对照组(1.59±0.25 mPa/S、6.98±0.29 mPa/S、3.74±1.11 mPa/S),治疗后1周、2周PSQI睡眠情况评分观察组(14.42±1.45分、8.63±1.66分)均低于对照组(16.64±1.41分、10.94±1.61分),母婴不良妊娠结局观察组(7.1%、5.4%)低于对照组(23.2%、17.9%)(均P<0.05)。结论:拉贝洛尔联合硝苯地平治疗HDCP效果提高,能够降低患者血压及血清炎性因子水平,改善睡眠质量与血液流变学情况,降低不良妊娠结局发生。

Objective:To investigate the effects of labetalol combined with nifedipine for treating pregnant women with gestational hypertension on their hemorheology,sleep quality,and pregnancy outcomes.Methods:A total of 112pregnant women with gestational hypertension were selected and were randomly divided into observation group(56cases treated with rabolol combined with nifedipine)and control group(56cases treated with nifedipine)by random number table method from January 2021to June 2022.The change of blood pressure before and after treatment,the levels of serum inflammatory factors,the hemorheology,the sleep quality,and the pregnancy outcomes of the women were compared between the two groups.Results:After 2weeks of treatment,the blood pressure value,and the levels of blood hs-CRP,TNF?α,and IL-12of the women in the observation group were significantly lower than those of the women in the control group.The plasma viscosity(1.31±0.33mPa/S),the whole blood low shear viscosity(6.57±0.17mPa/S),and the whole blood high shear viscosity(3.23±1.13mPa/S)of the women in the observation group were significantly lower than those(1.59±0.25mPa/S,6.98±0.29mPa/S,and 3.74±1.11mPa/S)of the women in the control group.1week and two weeks after treatment,the PSQI sleep scores of the women in the observation group were 14.42±1.45points and 8.63±1.66points,which were significantly lower than those(16.64±1.41points and 10.94±1.61points)of the women in the control group.1week and two weeks after treatment,the incidence of the adverse pregnancy outcomes of the women in the observation group were 7.1%and 5.4%,which were significantly lower than those(23.2%and 17.9%)of the women in the control group(all P<0.05).Conclusion:Labetalol combined with nifedipine for treating the pregnant women with gestational hypertension can increase their effect,reduce their blood pressure and serum inflammatory factors levels,improve their sleep quality and hemorheology,and reduce the incidence of their adverse pregnancy outcomes.