微纳米纤维复合人造血管的制备及力学性能研究

Preparation and Mechanical Propertiesof Micro-Nanofiber Composite Artificial Blood Vessels

为制备优良力学性能和耐穿刺性的小口径人造血管,本文通过自主研发的一体化人造血管编织机制备了一种微纳复合人造血管,改变湿法纺丝的挤出速度制备了不同丝径的卷绕内层,借助万能力学拉伸机对人造血管的力学性能以及耐穿刺性进行测试,同时还测试了人造血管支架的渗水性、动态顺应性等。实验结果表明,0.8mm丝径的微纳复合人造血管表现出了最优的结构稳定性、经向拉伸断裂强度、断裂伸长率、耐穿刺性能和水渗透性,其中经向拉伸断裂强度远优于天然动脉或静脉,断裂伸长率远优于涤纶和聚四氟乙烯人造血管,但是动态顺应性较差。

In order to prepare small-caliber artificial blood vessel with excellent mechanical properties and puncture resistance,a kind of micro-nano composite artificial blood vessel was prepared by a self-developed integrated artificial blood vesselweaving machine,the mechanical properties and puncture resistance of the artificial blood vessel were tested by universal mechanical drawing machine,the water permeability and dynamic compliance of the artificial vascular stent were also tested.The experimental results show that the 0.8 mm wire diameter micro/nano composite vascular prosthesis exhibits the best structural stability,tensile strength,elongation at break,puncture resistance and water permeability,the tensile strength was much better than that of natural arteries or veins,and the elongation at break was much better than that of Dacron and polytetrafluoroethylene artificial blood vessels,but the dynamic compliancewas poor.