基于粗糙集理论的正交设计提取工艺因素方法的研究

Study on extracting process factor method by orthogonal design based on rough set theory

目的研究药物制剂生产过程中因素之间的内在规律,探讨应用粗糙集理论寻求最优的工艺方案方法。方法以经典名方四物汤为例,利用正交设计试验预处理数据,建立决策表,利用粗糙集规则模型进行分析。结果当四物汤的提取时间、加水量和提取次数的因素水平逐渐增高时,多糖成分含量水平也呈递增趋势。当提取时间为1.5小时、加水量为1∶20、提取次数为2次时,试验结果最好,为四物汤优化提取工艺的三因素三水平最佳组合。结论应用粗糙集理论可以探究药物制剂生产工艺因素之间以及因素与试验结果之间的相关关系,更全面地揭示其内在动态规律,并提供一种新颖的研究方法,进一步提高药物制剂的工艺质量。

Objective To study the inherent law between factors in the pharmaceutical preparation production process,and explore the application of rough set theory to seek the optimal process plan method.Methods Take the classic recipe Siwu decoction as an example.Based on preprocessing data of the orthogonal design experiment,the decision table was established,and the rough set rule model was used to analyze.Results When the factor levels of the extraction time,the amount of water and the extraction times of Siwu decoction were gradually increased,the content of polysaccharide showed an increasing trend.When the extraction time was 1.5 hours,the amount of water was 1:20 and the extraction times were 2,the experimental results were the best and the best combination of three factors and three levels to optimize the extraction process of Siwu decoction.Conclusion Rough set theory can be applied to explore the correlation among factors of pharmaceutical production process and the correlation between factors and test results,to reveal its inherent dynamic law more comprehensively and provide a novel research method to further improve the quality of pharmaceutical preparations.